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2'-O-Methylation maintains ribosome structural and translation integrity.
Zhao Y, Rai J, Cohen LN, Shu Y, Xu C, Goswami H, Chen X, Jin H, Marchand V, Motorin Y, Ghalei H, Li H. Zhao Y, et al. Among authors: ghalei h. Mol Cell. 2026 Apr 16;86(8):1495-1510.e7. doi: 10.1016/j.molcel.2026.03.008. Epub 2026 Apr 1. Mol Cell. 2026. PMID: 41928510 Free PMC article.
EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA.
Runnebohm AM, Wijeratne HRS, Barron MP, Smith-Kinnaman WR, Rooney JD, Peck Justice SA, Cureton LA, Holland A, Ghalei H, Pelletier S, Doud EH, Vilseck JZ, Mosley AL. Runnebohm AM, et al. Among authors: ghalei h. bioRxiv [Preprint]. 2025 Jun 1:2025.05.31.657176. doi: 10.1101/2025.05.31.657176. bioRxiv. 2025. PMID: 40501579 Free PMC article. Preprint.
Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation.
Sterrett MC, Cureton LA, Cohen LN, van Hoof A, Khoshnevis S, Fasken MB, Corbett AH, Ghalei H. Sterrett MC, et al. Among authors: ghalei h. bioRxiv [Preprint]. 2025 Mar 19:2023.10.18.562946. doi: 10.1101/2023.10.18.562946. bioRxiv. 2025. Update in: RNA. 2025 Jun 16;31(7):988-1012. doi: 10.1261/rna.080447.125. PMID: 37904946 Free PMC article. Updated. Preprint.
TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion.
Khatib TO, Pedro BA, Bombin S, Matsuk VY, Robinson IE, Webster SF, Marcus LJ, Summerbell ER, Tharp GK, Knippler CM, Bagchi P, Kowalski-Muegge J, Johnston HR, Ghalei H, Vertino PM, Mouw JK, Marcus AI. Khatib TO, et al. Among authors: ghalei h. Cell Rep. 2025 Feb 25;44(2):115315. doi: 10.1016/j.celrep.2025.115315. Epub 2025 Feb 15. Cell Rep. 2025. PMID: 39955775 Free PMC article.
34 results