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Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells.
Aljada A, Ghanim H, Assian E, Dandona P. Aljada A, et al. Among authors: ghanim h. Metabolism. 2002 Apr;51(4):487-91. doi: 10.1053/meta.2002.31339. Metabolism. 2002. PMID: 11912559
Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations.
Aljada A, Ghanim H, Mohanty P, Kapur N, Dandona P. Aljada A, et al. Among authors: ghanim h. J Clin Endocrinol Metab. 2002 Mar;87(3):1419-22. doi: 10.1210/jcem.87.3.8462. J Clin Endocrinol Metab. 2002. PMID: 11889219
Insulin was infused at the rate of 2 IU/h in 5% dextrose (100 mL/h) and KCI (8 mmol/h) for 4 h in the fasting state in ten obese subjects. ...Plasma TF levels (basal = 100%) decreased to 76 +/- 7.7% of the basal level at 2 h and to 85 +/- 10.4% …
Insulin was infused at the rate of 2 IU/h in 5% dextrose (100 mL/h) and KCI (8 mmol/h) for 4 h in the fasting st …
Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells.
Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P. Mohanty P, et al. Among authors: ghanim h. Am J Clin Nutr. 2002 Apr;75(4):767-72. doi: 10.1093/ajcn/75.4.767. Am J Clin Nutr. 2002. PMID: 11916766 Clinical Trial.
RESULTS: ROS generation by MNCs and PMNs increased significantly 1, 2, and 3 h after cream intake and 1 h after protein intake. ...The increase in ROS generation lasted 3 h after cream intake and 1 h after protein intake. Cream intake also caused a sig …
RESULTS: ROS generation by MNCs and PMNs increased significantly 1, 2, and 3 h after cream intake and 1 h after protein intake …
Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action.
Dandona P, Kumar V, Aljada A, Ghanim H, Syed T, Hofmayer D, Mohanty P, Tripathy D, Garg R. Dandona P, et al. Among authors: ghanim h. J Clin Endocrinol Metab. 2003 Sep;88(9):4496-501. doi: 10.1210/jc.2002-021836. J Clin Endocrinol Metab. 2003. PMID: 12970329 Clinical Trial.
Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9.
Dandona P, Aljada A, Mohanty P, Ghanim H, Bandyopadhyay A, Chaudhuri A. Dandona P, et al. Among authors: ghanim h. Diabetes Care. 2003 Dec;26(12):3310-4. doi: 10.2337/diacare.26.12.3310. Diabetes Care. 2003. PMID: 14633819
RESEARCH DESIGN AND METHODS: Insulin was infused (2 IU/h) in 5% dextrose (100 ml/h) and KCl (8 mmol/h) into 10 fasting, obese, nondiabetic subjects for 4 h. ...Plasma MMP-9 concentrations decreased from 375 +/- 196.3 ng/ml (100%) at 0 h to 83 +/ …
RESEARCH DESIGN AND METHODS: Insulin was infused (2 IU/h) in 5% dextrose (100 ml/h) and KCl (8 mmol/h) into 10 fasting, …
Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects.
Tripathy D, Mohanty P, Dhindsa S, Syed T, Ghanim H, Aljada A, Dandona P. Tripathy D, et al. Among authors: ghanim h. Diabetes. 2003 Dec;52(12):2882-7. doi: 10.2337/diabetes.52.12.2882. Diabetes. 2003. PMID: 14633847

NF-kappaB p65 subunit protein expression in MNC homogenates also increased at 2, 4, and 6 h (P < 0.05). ROS generation by PMNs increased significantly at 2 and 4 h (P < 0.005), whereas that by MNCs increased at 4 h (P < 0.05). Plasma macrophage migra

NF-kappaB p65 subunit protein expression in MNC homogenates also increased at 2, 4, and 6 h (P < 0.05). ROS generation by PMNs inc

Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappaB in mononuclear cells.
Dhindsa S, Tripathy D, Mohanty P, Ghanim H, Syed T, Aljada A, Dandona P. Dhindsa S, et al. Among authors: ghanim h. Metabolism. 2004 Mar;53(3):330-4. doi: 10.1016/j.metabol.2003.10.013. Metabolism. 2004. PMID: 15015145
Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.
Aljada A, Mohanty P, Ghanim H, Abdo T, Tripathy D, Chaudhuri A, Dandona P. Aljada A, et al. Among authors: ghanim h. Am J Clin Nutr. 2004 Apr;79(4):682-90. doi: 10.1093/ajcn/79.4.682. Am J Clin Nutr. 2004. PMID: 15051615 Clinical Trial.
Blood samples were collected at 0, 1, 2, and 3 h. ROS generation by mononuclear cells and polymorphonuclear leukocytes and the expression of p47(phox) subunit were measured. ...
Blood samples were collected at 0, 1, 2, and 3 h. ROS generation by mononuclear cells and polymorphonuclear leukocytes and the expres …
Evidence for a potent antiinflammatory effect of rosiglitazone.
Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, Al-Haddad W, Dhindsa S, Dandona P. Mohanty P, et al. Among authors: ghanim h. J Clin Endocrinol Metab. 2004 Jun;89(6):2728-35. doi: 10.1210/jc.2003-032103. J Clin Endocrinol Metab. 2004. PMID: 15181049 Clinical Trial.
Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations.
Aljada A, Ghanim H, Mohanty P, Syed T, Bandyopadhyay A, Dandona P. Aljada A, et al. Among authors: ghanim h. Am J Clin Nutr. 2004 Jul;80(1):51-7. doi: 10.1093/ajcn/80.1.51. Am J Clin Nutr. 2004. PMID: 15213027
RESULTS: AP-1 and Egr-1 binding activities were significantly higher 1 and 2 h after glucose intake and then decreased toward the baseline by 3 h. The expression of MMP-2 and TF in MNC homogenates also was significantly higher at 2 and 3 h. Plasma concentrati …
RESULTS: AP-1 and Egr-1 binding activities were significantly higher 1 and 2 h after glucose intake and then decreased toward the bas …
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