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Met, metastasis, motility and more.
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. Birchmeier C, et al. Among authors: gherardi e. Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25. doi: 10.1038/nrm1261. Nat Rev Mol Cell Biol. 2003. PMID: 14685170 Review. No abstract available.
Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
Andres F, Iamele L, Meyer T, Stüber JC, Kast F, Gherardi E, Niemann HH, Plückthun A. Andres F, et al. Among authors: gherardi e. J Mol Biol. 2019 May 3;431(10):2020-2039. doi: 10.1016/j.jmb.2019.03.024. Epub 2019 Mar 28. J Mol Biol. 2019. PMID: 30930049
Structural basis of hepatocyte growth factor/scatter factor and MET signalling.
Gherardi E, Sandin S, Petoukhov MV, Finch J, Youles ME, Ofverstedt LG, Miguel RN, Blundell TL, Vande Woude GF, Skoglund U, Svergun DI. Gherardi E, et al. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4046-51. doi: 10.1073/pnas.0509040103. Epub 2006 Mar 6. Proc Natl Acad Sci U S A. 2006. PMID: 16537482 Free PMC article.
Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
DiCara DM, Chirgadze DY, Pope AR, Karatt-Vellatt A, Winter A, Slavny P, van den Heuvel J, Parthiban K, Holland J, Packman LC, Mavria G, Hoffmann J, Birchmeier W, Gherardi E, McCafferty J. DiCara DM, et al. Among authors: gherardi e. Sci Rep. 2017 Aug 21;7(1):9000. doi: 10.1038/s41598-017-09460-2. Sci Rep. 2017. PMID: 28827556 Free PMC article.
Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach.
Winter A, Sigurdardottir AG, DiCara D, Valenti G, Blundell TL, Gherardi E. Winter A, et al. Among authors: gherardi e. Mol Cancer Ther. 2016 Jan;15(1):3-14. doi: 10.1158/1535-7163.MCT-15-0446. Epub 2015 Dec 28. Mol Cancer Ther. 2016. PMID: 26712116 Free article.
Targeting MET in cancer: rationale and progress.
Gherardi E, Birchmeier W, Birchmeier C, Vande Woude G. Gherardi E, et al. Nat Rev Cancer. 2012 Jan 24;12(2):89-103. doi: 10.1038/nrc3205. Nat Rev Cancer. 2012. PMID: 22270953 Review.
Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist.
Youles M, Holmes O, Petoukhov MV, Nessen MA, Stivala S, Svergun DI, Gherardi E. Youles M, et al. Among authors: gherardi e. J Mol Biol. 2008 Mar 28;377(3):616-22. doi: 10.1016/j.jmb.2008.01.034. Epub 2008 Jan 18. J Mol Biol. 2008. PMID: 18291418
A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping.
Watanabe K, Chirgadze DY, Lietha D, de Jonge H, Blundell TL, Gherardi E. Watanabe K, et al. Among authors: gherardi e. J Mol Biol. 2002 May 31;319(2):283-8. doi: 10.1016/S0022-2836(02)00199-7. J Mol Biol. 2002. PMID: 12051906
Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB.
Niemann HH, Jäger V, Butler PJ, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW. Niemann HH, et al. Among authors: gherardi e. Cell. 2007 Jul 27;130(2):235-46. doi: 10.1016/j.cell.2007.05.037. Cell. 2007. PMID: 17662939
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