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Synthesis of Derivatives of the Antibiotic Albicidin: The N-Terminal Fragment as Key to Control Potency and Resistance Mediated by the Binding Protein AlbA.
Kulike-Koczula M, Hommernick K, Ghimire LB, Kosol S, Zborovsky L, Seidel M, Sattler N, Mainz A, Weston JB, Ghilarov D, Süssmuth RD. Kulike-Koczula M, et al. Among authors: ghilarov d. Chemistry. 2025 Apr 9;31(21):e202500162. doi: 10.1002/chem.202500162. Epub 2025 Mar 11. Chemistry. 2025. PMID: 40024889 Free PMC article.
Molecular basis of foreign DNA recognition by BREX anti-phage immunity system.
Drobiazko A, Adams MC, Skutel M, Potekhina K, Kotovskaya O, Trofimova A, Matlashov M, Yatselenko D, Maxwell KL, Blower TR, Severinov K, Ghilarov D, Isaev A. Drobiazko A, et al. Among authors: ghilarov d. Nat Commun. 2025 Feb 20;16(1):1825. doi: 10.1038/s41467-025-57006-2. Nat Commun. 2025. PMID: 39979294 Free PMC article.
Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria.
Bakker AT, Kotsogianni I, Avalos M, Punt JM, Liu B, Piermarini D, Gagestein B, Slingerland CJ, Zhang L, Willemse JJ, Ghimire LB, van den Berg RJHBN, Janssen APA, Ottenhoff THM, van Boeckel CAA, van Wezel GP, Ghilarov D, Martin NI, van der Stelt M. Bakker AT, et al. Among authors: ghilarov d. Nat Chem. 2024 Sep;16(9):1462-1472. doi: 10.1038/s41557-024-01516-x. Epub 2024 Jun 19. Nat Chem. 2024. PMID: 38898213 Free PMC article.
Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria.
Saathoff M, Kosol S, Semmler T, Tedin K, Dimos N, Kupke J, Seidel M, Ghazisaeedi F, Jonske MC, Wolf SA, Kuropka B, Czyszczoń W, Ghilarov D, Grätz S, Heddle JG, Loll B, Süssmuth RD, Fulde M. Saathoff M, et al. Among authors: ghilarov d. PLoS Biol. 2023 Aug 10;21(8):e3002186. doi: 10.1371/journal.pbio.3002186. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37561817 Free PMC article.
Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin.
Michalczyk E, Hommernick K, Behroz I, Kulike M, Pakosz-Stępień Z, Mazurek L, Seidel M, Kunert M, Santos K, von Moeller H, Loll B, Weston JB, Mainz A, Heddle JG, Süssmuth RD, Ghilarov D. Michalczyk E, et al. Among authors: ghilarov d. Nat Catal. 2023;6(1):52-67. doi: 10.1038/s41929-022-00904-1. Epub 2023 Jan 23. Nat Catal. 2023. PMID: 36741192 Free PMC article.
19 results