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Pulmonary oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular disease.
Shannahan JH, Schladweiler MC, Richards JH, Ledbetter AD, Ghio AJ, Kodavanti UP. Shannahan JH, et al. J Toxicol Environ Health A. 2010;73(10):641-56. doi: 10.1080/15287390903578208. J Toxicol Environ Health A. 2010. PMID: 20391109
Underlying cardiovascular disease (CVD) is a risk factor for the exacerbation of air pollution health effects. Pulmonary oxidative stress, inflammation, and altered iron (Fe) homeostasis secondary to CVD may influence mammalian susceptibility to air pollutants. ...This stu …
Underlying cardiovascular disease (CVD) is a risk factor for the exacerbation of air pollution health effects. Pulmonary oxidative st …
Macrophages from the upper and lower human respiratory tract are metabolically distinct.
Lavrich KS, Speen AM, Ghio AJ, Bromberg PA, Samet JM, Alexis NE. Lavrich KS, et al. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L752-L764. doi: 10.1152/ajplung.00208.2018. Epub 2018 Aug 9. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 30091382 Free PMC article.
These findings establish a regional bioenergetic profile for macrophages from healthy human airways that serves as a reference for changes that occur in disease....
These findings establish a regional bioenergetic profile for macrophages from healthy human airways that serves as a reference …
Exercise-induced pulmonary hemorrhage after running a marathon.
Ghio AJ, Ghio C, Bassett M. Ghio AJ, et al. Lung. 2006 Nov-Dec;184(6):331-3. doi: 10.1007/s00408-006-0023-2. Epub 2006 Nov 3. Lung. 2006. PMID: 17086462
We report on a healthy 26-year-old male who had an exercise-induced pulmonary hemorrhage (EIPH) within 24 hours of running a marathon. ...
We report on a healthy 26-year-old male who had an exercise-induced pulmonary hemorrhage (EIPH) within 24 hours of running a m …
Acute phase reaction in healthy volunteers after bronchoscopy with lavage.
Huang YC, Bassett MA, Levin D, Montilla T, Ghio AJ. Huang YC, et al. Chest. 2006 Jun;129(6):1565-9. doi: 10.1378/chest.129.6.1565. Chest. 2006. PMID: 16778276 Clinical Trial.
SETTING: A human study research facility. PARTICIPANTS: Normal nonsmoking volunteers. INTERVENTION: A total of 28 subjects were recruited. ...CONCLUSIONS: Bronchoscopy with BAL induces a variety of acute phase responses that includes peripheral neutrophilia, …
SETTING: A human study research facility. PARTICIPANTS: Normal nonsmoking volunteers. INTERVENTION: A total of 28 subjects wer …
Lung injury after ozone exposure is iron dependent.
Ghio AJ, Turi JL, Madden MC, Dailey LA, Richards JD, Stonehuerner JG, Morgan DL, Singleton S, Garrick LM, Garrick MD. Ghio AJ, et al. Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L134-43. doi: 10.1152/ajplung.00534.2005. Epub 2006 Aug 11. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 16905637
Iron homeostasis was disrupted to a greater extent and the extent of injury was greater in Belgrade rats than in control rats. ...Human embryonic kidney (HEK 293) cells with elevated expression of a DMT1 construct were exposed to filtered air and O3. With exposure t …
Iron homeostasis was disrupted to a greater extent and the extent of injury was greater in Belgrade rats than in control rats. ...Hum …
Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues.
Yu YR, Hotten DF, Malakhau Y, Volker E, Ghio AJ, Noble PW, Kraft M, Hollingsworth JW, Gunn MD, Tighe RM. Yu YR, et al. Am J Respir Cell Mol Biol. 2016 Jan;54(1):13-24. doi: 10.1165/rcmb.2015-0146OC. Am J Respir Cell Mol Biol. 2016. PMID: 26267148 Free PMC article.
A well-defined flow cytometry panel for myeloid cells in human bronchoalveolar lavage (BAL) and lung tissue is currently lacking. The objective of this study was to develop a flow cytometry-based panel for human BAL and lung tissue. We obtained and performed flow cy
A well-defined flow cytometry panel for myeloid cells in human bronchoalveolar lavage (BAL) and lung tissue is currently lacking. The
Progress in assessing air pollutant risks from in vitro exposures: matching ozone dose and effect in human airway cells.
Hatch GE, Duncan KE, Diaz-Sanchez D, Schmitt MT, Ghio AJ, Carraway MS, McKee J, Dailey LA, Berntsen J, Devlin RB. Hatch GE, et al. Toxicol Sci. 2014 Sep;141(1):198-205. doi: 10.1093/toxsci/kfu115. Epub 2014 Jun 13. Toxicol Sci. 2014. PMID: 24928893 Free PMC article.
In vitro exposures to air pollutants could, in theory, facilitate a rapid and detailed assessment of molecular mechanisms of toxicity. However, it is difficult to ensure that the dose of a gaseous pollutant to cells in tissue culture is similar to that of the same c …
In vitro exposures to air pollutants could, in theory, facilitate a rapid and detailed assessment of molecular mechanisms of toxicity …
Host and environmental factors affect pulmonary responses measured in bronchoalveolar lavage.
Huang JJ, Soukup JM, Ghio AJ, Huang YC. Huang JJ, et al. Inhal Toxicol. 2014 Jan;26(1):30-5. doi: 10.3109/08958378.2013.851304. Inhal Toxicol. 2014. PMID: 24417405
MATERIALS AND METHODS: We retrospectively analyzed 77 healthy non-smoking volunteers (38 males and 39 females, age 18-35) who participated in a bronchoscopy study to donate cells for in vitro studies. ...
MATERIALS AND METHODS: We retrospectively analyzed 77 healthy non-smoking volunteers (38 males and 39 females, age 18-35) who participated i …
Diesel exhaust particles and airway inflammation.
Ghio AJ, Smith CB, Madden MC. Ghio AJ, et al. Curr Opin Pulm Med. 2012 Mar;18(2):144-50. doi: 10.1097/MCP.0b013e32834f0e2a. Curr Opin Pulm Med. 2012. PMID: 22234273 Review.
The capacity of diesel exhaust particles (DEPs), a major emission source air pollution particle, to initiate an airway inflammation has subsequently been investigated. ...The lack of a biological response to DEPs at lower concentrations may reflect a contribu …
The capacity of diesel exhaust particles (DEPs), a major emission source air pollution particle, to initiate an airway inflammation h …
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