Ghosh AK - Search Results

1

Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.

Koh Y, Matsumi S, Das D, Amano M, Davis DA, Li J, Leschenko S, Baldridge A, Shioda T, Yarchoan R, Ghosh AK, Mitsuya H. Koh Y, et al. Among authors: ghosh ak. J Biol Chem. 2007 Sep 28;282(39):28709-28720. doi: 10.1074/jbc.M703938200. Epub 2007 Jul 17. J Biol Chem. 2007. PMID: 17635930 Free article.

2

Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.

Ghosh AK, Thompson WJ, Holloway MK, McKee SP, Duong TT, Lee HY, Munson PM, Smith AM, Wai JM, Darke PL, et al. Ghosh AK, et al. J Med Chem. 1993 Aug 6;36(16):2300-10. doi: 10.1021/jm00068a006. J Med Chem. 1993. PMID: 8360874

3

A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.

Yoshimura K, Kato R, Kavlick MF, Nguyen A, Maroun V, Maeda K, Hussain KA, Ghosh AK, Gulnik SV, Erickson JW, Mitsuya H. Yoshimura K, et al. Among authors: ghosh ak. J Virol. 2002 Feb;76(3):1349-58. doi: 10.1128/jvi.76.3.1349-1358.2002. J Virol. 2002. PMID: 11773409 Free PMC article.

4

Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

Koh Y, Nakata H, Maeda K, Ogata H, Bilcer G, Devasamudram T, Kincaid JF, Boross P, Wang YF, Tie Y, Volarath P, Gaddis L, Harrison RW, Weber IT, Ghosh AK, Mitsuya H. Koh Y, et al. Among authors: ghosh ak. Antimicrob Agents Chemother. 2003 Oct;47(10):3123-9. doi: 10.1128/AAC.47.10.3123-3129.2003. Antimicrob Agents Chemother. 2003. PMID: 14506019 Free PMC article.

5

Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.

Ghosh AK, Swanson LM, Cho H, Leshchenko S, Hussain KA, Kay S, Walters DE, Koh Y, Mitsuya H. Ghosh AK, et al. J Med Chem. 2005 May 19;48(10):3576-85. doi: 10.1021/jm050019i. J Med Chem. 2005. PMID: 15887965

6

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.

Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. J Med Chem. 2005 Nov 3;48(22):6767-71. doi: 10.1021/jm050548m. J Med Chem. 2005. PMID: 16250632

7

Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop.

Gatanaga H, Das D, Suzuki Y, Yeh DD, Hussain KA, Ghosh AK, Mitsuya H. Gatanaga H, et al. Among authors: ghosh ak. J Biol Chem. 2006 Jan 13;281(2):1241-50. doi: 10.1074/jbc.M505920200. Epub 2005 Nov 7. J Biol Chem. 2006. PMID: 16275650 Free article.

8

Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.

Ghosh AK, Schiltz G, Perali RS, Leshchenko S, Kay S, Walters DE, Koh Y, Maeda K, Mitsuya H. Ghosh AK, et al. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1869-73. doi: 10.1016/j.bmcl.2006.01.011. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480871

9

Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.

Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H. Ghosh AK, et al. J Med Chem. 2006 Aug 24;49(17):5252-61. doi: 10.1021/jm060561m. J Med Chem. 2006. PMID: 16913714

10

Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance.

Ghosh AK, Ramu Sridhar P, Kumaragurubaran N, Koh Y, Weber IT, Mitsuya H. Ghosh AK, et al. ChemMedChem. 2006 Sep;1(9):939-50. doi: 10.1002/cmdc.200600103. ChemMedChem. 2006. PMID: 16927344 Review. No abstract available.

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