Sucrose-free low-fat diet induces metabolic dysfunction through gut dysbiosis and colonic inflammation in mice.
Almansour N, Kochumon S, Al-Rashed F, Malik MZ, Benobaid N, Shenouda S, Thomas R, Arefanian H, Nizam R, Jacob T, Al Madhoun A, Tuomilehto J, Al-Mulla F, Ahmad R.
Almansour N, et al.
Front Immunol. 2026 Jul 21;17:1813722. doi: 10.3389/fimmu.2026.1813722. eCollection 2026.
Front Immunol. 2026.
PMID: 42553085
Free PMC article.
Despite unchanged body and liver weights, SF-LFD feeding resulted in impaired glucose tolerance, reduced insulin sensitivity, and broad alterations in circulating metabolic hormones, including elevated C-peptide, incretins, ghrelin, and resistin, as well as reduced fasting …
Despite unchanged body and liver weights, SF-LFD feeding resulted in impaired glucose tolerance, reduced insulin sensitivity, and broad alte …