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A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74.
Bosselut R, Levin J, Adjadj E, Ghysdael J. Bosselut R, et al. Nucleic Acids Res. 1993 Nov 11;21(22):5184-91. doi: 10.1093/nar/21.22.5184. Nucleic Acids Res. 1993. PMID: 8255775 Free PMC article.
FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family.
van den Akker E, Ano S, Shih HM, Wang LC, Pironin M, Palvimo JJ, Kotaja N, Kirsh O, Dejean A, Ghysdael J. van den Akker E, et al. J Biol Chem. 2005 Nov 11;280(45):38035-46. doi: 10.1074/jbc.M502938200. Epub 2005 Sep 7. J Biol Chem. 2005. PMID: 16148010
Erythroblast transformation by FLI-1 depends upon its specific DNA binding and transcriptional activation properties.
Ano S, Pereira R, Pironin M, Lesault I, Milley C, Lebigot I, Quang CT, Ghysdael J. Ano S, et al. J Biol Chem. 2004 Jan 23;279(4):2993-3002. doi: 10.1074/jbc.M303816200. Epub 2003 Oct 21. J Biol Chem. 2004. PMID: 14570912
Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling.
Lebigot I, Gardellin P, Lefebvre L, Beug H, Ghysdael J, Quang CT. Lebigot I, et al. Blood. 2003 Dec 15;102(13):4555-62. doi: 10.1182/blood-2003-06-2077. Epub 2003 Aug 28. Blood. 2003. PMID: 12946994
The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.
Salomon-Nguyen F, Della-Valle V, Mauchauffe M, Busson-Le Coniat M, Ghysdael J, Berger R, Bernard OA. Salomon-Nguyen F, et al. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6757-62. doi: 10.1073/pnas.120162297. Proc Natl Acad Sci U S A. 2000. PMID: 10829078 Free PMC article.
TEL is a sequence-specific transcriptional repressor.
Lopez RG, Carron C, Oury C, Gardellin P, Bernard O, Ghysdael J. Lopez RG, et al. J Biol Chem. 1999 Oct 15;274(42):30132-8. doi: 10.1074/jbc.274.42.30132. J Biol Chem. 1999. PMID: 10514502
A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.
Jousset C, Carron C, Boureux A, Quang CT, Oury C, Dusanter-Fourt I, Charon M, Levin J, Bernard O, Ghysdael J. Jousset C, et al. EMBO J. 1997 Jan 2;16(1):69-82. doi: 10.1093/emboj/16.1.69. EMBO J. 1997. PMID: 9009269 Free PMC article.
Tissue-specific activity of the gammac chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein.
Markiewicz S, Bosselut R, Le Deist F, de Villartay JP, Hivroz C, Ghysdael J, Fischer A, de Saint Basile G. Markiewicz S, et al. J Biol Chem. 1996 Jun 21;271(25):14849-55. doi: 10.1074/jbc.271.25.14849. J Biol Chem. 1996. PMID: 8663060
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