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319 results
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HIF-1 as a target for drug development.
Giaccia A, Siim BG, Johnson RS. Giaccia A, et al. Nat Rev Drug Discov. 2003 Oct;2(10):803-11. doi: 10.1038/nrd1199. Nat Rev Drug Discov. 2003. PMID: 14526383 Review.
Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.
Murphy BJ, Andrews GK, Bittel D, Discher DJ, McCue J, Green CJ, Yanovsky M, Giaccia A, Sutherland RM, Laderoute KR, Webster KA. Murphy BJ, et al. Among authors: giaccia a. Cancer Res. 1999 Mar 15;59(6):1315-22. Cancer Res. 1999. PMID: 10096565
Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.
Denko N, Schindler C, Koong A, Laderoute K, Green C, Giaccia A. Denko N, et al. Among authors: giaccia a. Clin Cancer Res. 2000 Feb;6(2):480-7. Clin Cancer Res. 2000. PMID: 10690527
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.
Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M, Derr J, Taya Y, Lowe SW, Kastan M, Giaccia A. Koumenis C, et al. Among authors: giaccia a. Mol Cell Biol. 2001 Feb;21(4):1297-310. doi: 10.1128/MCB.21.4.1297-1310.2001. Mol Cell Biol. 2001. PMID: 11158315 Free PMC article.
Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis.
Koumenis C, Giaccia A. Koumenis C, et al. Among authors: giaccia a. Mol Cell Biol. 1997 Dec;17(12):7306-16. doi: 10.1128/mcb.17.12.7306. Mol Cell Biol. 1997. PMID: 9372962 Free PMC article.
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
Brown JM, Giaccia AJ. Brown JM, et al. Among authors: giaccia aj. Cancer Res. 1998 Apr 1;58(7):1408-16. Cancer Res. 1998. PMID: 9537241 Review.
PHD2 in tumour angiogenesis.
Chan DA, Giaccia AJ. Chan DA, et al. Among authors: giaccia aj. Br J Cancer. 2010 Jun 29;103(1):1-5. doi: 10.1038/sj.bjc.6605682. Epub 2010 May 11. Br J Cancer. 2010. PMID: 20461086 Free PMC article. Review.
The role of hypoxia-inducible factors in tumorigenesis.
Rankin EB, Giaccia AJ. Rankin EB, et al. Among authors: giaccia aj. Cell Death Differ. 2008 Apr;15(4):678-85. doi: 10.1038/cdd.2008.21. Epub 2008 Feb 15. Cell Death Differ. 2008. PMID: 18259193 Free PMC article. Review.
Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency.
Popovici RM, Lu M, Bhatia S, Faessen GH, Giaccia AJ, Giudice LC. Popovici RM, et al. Among authors: giaccia aj. J Clin Endocrinol Metab. 2001 Jun;86(6):2653-9. doi: 10.1210/jcem.86.6.7526. J Clin Endocrinol Metab. 2001. PMID: 11397868
Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis.
Denko NC, Giaccia AJ. Denko NC, et al. Among authors: giaccia aj. Cancer Res. 2001 Feb 1;61(3):795-8. Cancer Res. 2001. PMID: 11221857 Review. No abstract available.
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