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Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.
Murphy BJ, Andrews GK, Bittel D, Discher DJ, McCue J, Green CJ, Yanovsky M, Giaccia A, Sutherland RM, Laderoute KR, Webster KA. Murphy BJ, et al. Cancer Res. 1999 Mar 15;59(6):1315-22. Cancer Res. 1999. PMID: 10096565
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.
Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M, Derr J, Taya Y, Lowe SW, Kastan M, Giaccia A. Koumenis C, et al. Mol Cell Biol. 2001 Feb;21(4):1297-310. doi: 10.1128/MCB.21.4.1297-1310.2001. Mol Cell Biol. 2001. PMID: 11158315 Free PMC article.
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress.
Zundel W, Giaccia A. Zundel W, et al. Genes Dev. 1998 Jul 1;12(13):1941-6. doi: 10.1101/gad.12.13.1941. Genes Dev. 1998. PMID: 9649498 Free PMC article.
Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma.
Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E. Zhou L, et al. Oncogene. 2016 May;35(21):2687-97. doi: 10.1038/onc.2015.343. Epub 2015 Sep 14. Oncogene. 2016. PMID: 26364599 Free PMC article.
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