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Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood.
Tata B, Mimouni NEH, Barbotin AL, Malone SA, Loyens A, Pigny P, Dewailly D, Catteau-Jonard S, Sundström-Poromaa I, Piltonen TT, Dal Bello F, Medana C, Prevot V, Clasadonte J, Giacobini P. Tata B, et al. Among authors: giacobini p. Nat Med. 2018 Jun;24(6):834-846. doi: 10.1038/s41591-018-0035-5. Epub 2018 May 14. Nat Med. 2018. PMID: 29760445 Free PMC article.
SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.
Hanchate NK, Giacobini P, Lhuillier P, Parkash J, Espy C, Fouveaut C, Leroy C, Baron S, Campagne C, Vanacker C, Collier F, Cruaud C, Meyer V, García-Piñero A, Dewailly D, Cortet-Rudelli C, Gersak K, Metz C, Chabrier G, Pugeat M, Young J, Hardelin JP, Prevot V, Dodé C. Hanchate NK, et al. Among authors: giacobini p. PLoS Genet. 2012 Aug;8(8):e1002896. doi: 10.1371/journal.pgen.1002896. Epub 2012 Aug 23. PLoS Genet. 2012. PMID: 22927827 Free PMC article.
Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A.
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Giacobini P, et al. PLoS Biol. 2014 Mar 11;12(3):e1001808. doi: 10.1371/journal.pbio.1001808. eCollection 2014 Mar. PLoS Biol. 2014. PMID: 24618750 Free PMC article.
Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong F, Cagnoni G, Schellino R, De Marchis S, Mazzone M, Pasterkamp RJ, Tamagnone L, Prevot V, Giacobini P. Parkash J, et al. Among authors: giacobini p. Nat Commun. 2015 Feb 27;6:6385. doi: 10.1038/ncomms7385. Nat Commun. 2015. PMID: 25721933 Free PMC article.
Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.
Boehm U, Bouloux PM, Dattani MT, de Roux N, Dodé C, Dunkel L, Dwyer AA, Giacobini P, Hardelin JP, Juul A, Maghnie M, Pitteloud N, Prevot V, Raivio T, Tena-Sempere M, Quinton R, Young J. Boehm U, et al. Among authors: giacobini p. Nat Rev Endocrinol. 2015 Sep;11(9):547-64. doi: 10.1038/nrendo.2015.112. Epub 2015 Jul 21. Nat Rev Endocrinol. 2015. PMID: 26194704 Review.
A microRNA switch regulates the rise in hypothalamic GnRH production before puberty.
Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Tena-Sempere M, Giacobini P, Prevot V. Messina A, et al. Among authors: giacobini p. Nat Neurosci. 2016 Jun;19(6):835-44. doi: 10.1038/nn.4298. Epub 2016 May 2. Nat Neurosci. 2016. PMID: 27135215 Free article.
81 results