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Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.
Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Clark AG, Herskowitz I, Giacomini KM; Pharmacogenetics of Membrane Transporters Investigators. Leabman MK, et al. Among authors: giacomini km. Pharmacogenetics. 2002 Jul;12(5):395-405. doi: 10.1097/00008571-200207000-00007. Pharmacogenetics. 2002. PMID: 12142729
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM; Pharmacogenetics Of Membrane Transporters Investigators. Leabman MK, et al. Among authors: giacomini km. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5896-901. doi: 10.1073/pnas.0730857100. Epub 2003 Apr 28. Proc Natl Acad Sci U S A. 2003. PMID: 12719533 Free PMC article.
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.
Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM; Pharmacogenetics Of Membrane Transporters Investigators. Shu Y, et al. Among authors: giacomini km. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5902-7. doi: 10.1073/pnas.0730858100. Epub 2003 Apr 28. Proc Natl Acad Sci U S A. 2003. PMID: 12719534 Free PMC article.
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG; Pharmacogenetics of Membrane Transporters Investigators. Kroetz DL, et al. Among authors: giacomini km. Pharmacogenetics. 2003 Aug;13(8):481-94. doi: 10.1097/00008571-200308000-00006. Pharmacogenetics. 2003. PMID: 12893986
344 results