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Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation.
Chiarugi P, Cirri P, Taddei ML, Giannoni E, Fiaschi T, Buricchi F, Camici G, Raugei G, Ramponi G. Chiarugi P, et al. Among authors: giannoni e. J Biol Chem. 2002 Oct 4;277(40):37331-8. doi: 10.1074/jbc.M205203200. Epub 2002 Jul 30. J Biol Chem. 2002. PMID: 12149261
LMW-PTP is a positive regulator of tumor onset and growth.
Chiarugi P, Taddei ML, Schiavone N, Papucci L, Giannoni E, Fiaschi T, Capaccioli S, Raugei G, Ramponi G. Chiarugi P, et al. Among authors: giannoni e. Oncogene. 2004 May 13;23(22):3905-14. doi: 10.1038/sj.onc.1207508. Oncogene. 2004. PMID: 15021900
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