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Single-dose pharmacokinetics of varenicline, a selective nicotinic receptor partial agonist, in healthy smokers and nonsmokers.
Faessel HM, Smith BJ, Gibbs MA, Gobey JS, Clark DJ, Burstein AH. Faessel HM, et al. Among authors: gibbs ma. J Clin Pharmacol. 2006 Sep;46(9):991-8. doi: 10.1177/0091270006290669. J Clin Pharmacol. 2006. PMID: 16920893 Clinical Trial.
Impact of Target-Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).
Gibbs JP, Doshi S, Kuchimanchi M, Grover A, Emery MG, Dodds MG, Gibbs MA, Somaratne R, Wasserman SM, Blom D. Gibbs JP, et al. Among authors: gibbs ma. J Clin Pharmacol. 2017 May;57(5):616-626. doi: 10.1002/jcph.840. Epub 2016 Nov 15. J Clin Pharmacol. 2017. PMID: 27861991 Free PMC article. Clinical Trial.
A semi-mechanistic model to characterize the pharmacokinetics and pharmacodynamics of brodalumab in healthy volunteers and subjects with psoriasis in a first-in-human single ascending dose study.
Salinger DH, Endres CJ, Martin DA, Gibbs MA. Salinger DH, et al. Among authors: gibbs ma. Clin Pharmacol Drug Dev. 2014 Jul;3(4):276-83. doi: 10.1002/cpdd.103. Epub 2014 Feb 18. Clin Pharmacol Drug Dev. 2014. PMID: 27128833 Clinical Trial.
Population pharmacokinetics of brodalumab in healthy adults and adults with psoriasis from single and multiple dose studies.
Endres CJ, Salinger DH, Köck K, Gastonguay MR, Martin DA, Klekotka P, Nirula A, Gibbs MA. Endres CJ, et al. Among authors: gibbs ma. J Clin Pharmacol. 2014 Nov;54(11):1230-8. doi: 10.1002/jcph.334. Epub 2014 May 27. J Clin Pharmacol. 2014. PMID: 24846347 Clinical Trial.
Quantitative model of the relationship between dipeptidyl peptidase-4 (DPP-4) inhibition and response: meta-analysis of alogliptin, saxagliptin, sitagliptin, and vildagliptin efficacy results.
Gibbs JP, Fredrickson J, Barbee T, Correa I, Smith B, Lin SL, Gibbs MA. Gibbs JP, et al. Among authors: gibbs ma. J Clin Pharmacol. 2012 Oct;52(10):1494-505. doi: 10.1177/0091270011420153. Epub 2011 Dec 12. J Clin Pharmacol. 2012. PMID: 22162539 Clinical Trial.
Population pharmacokinetic/pharmacodynamic model of subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity after oral administration of AMG 221, a selective 11β-HSD1 inhibitor.
Gibbs JP, Emery MG, McCaffery I, Smith B, Gibbs MA, Akrami A, Rossi J, Paweletz K, Gastonguay MR, Bautista E, Wang M, Perfetti R, Daniels O. Gibbs JP, et al. Among authors: gibbs ma. J Clin Pharmacol. 2011 Jun;51(6):830-41. doi: 10.1177/0091270010374470. Epub 2010 Jul 27. J Clin Pharmacol. 2011. PMID: 20663992 Clinical Trial.
Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction.
Dong JQ, Salinger DH, Endres CJ, Gibbs JP, Hsu CP, Stouch BJ, Hurh E, Gibbs MA. Dong JQ, et al. Among authors: gibbs jp, gibbs ma. Clin Pharmacokinet. 2011 Feb;50(2):131-42. doi: 10.2165/11537430-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21241072
Pharmacokinetics, Immunogenicity, and Efficacy of Etanercept in Pediatric Patients With Moderate to Severe Plaque Psoriasis.
Langley RG, Kasichayanula S, Trivedi M, Aras GA, Kaliyaperumal A, Yuraszeck T, Gibbs J, Gibbs M, Kricorian G, Paller AS. Langley RG, et al. Among authors: gibbs j, gibbs m. J Clin Pharmacol. 2018 Mar;58(3):340-346. doi: 10.1002/jcph.1029. Epub 2017 Nov 6. J Clin Pharmacol. 2018. PMID: 29106714 Clinical Trial.
Ignorance is not bliss: Statistical power is not probability of trial success.
Zierhut ML, Bycott P, Gibbs MA, Smith BP, Vicini P. Zierhut ML, et al. Among authors: gibbs ma. Clin Pharmacol Ther. 2016 Apr;99(4):356-9. doi: 10.1002/cpt.257. Epub 2015 Oct 23. Clin Pharmacol Ther. 2016. PMID: 26331445
Factors affecting the clinical development of cytochrome p450 3A substrates.
Gibbs MA, Hosea NA. Gibbs MA, et al. Clin Pharmacokinet. 2003;42(11):969-84. doi: 10.2165/00003088-200342110-00003. Clin Pharmacokinet. 2003. PMID: 12908853 Review.
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