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Grignard-mediated synthesis and preliminary biological evaluation of novel 3-substituted farnesyl diphosphate analogues.
Zahn TJ, Weinbaum C, Gibbs RA. Zahn TJ, et al. Among authors: gibbs ra. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1763-6. doi: 10.1016/s0960-894x(00)00337-1. Bioorg Med Chem Lett. 2000. PMID: 10937743
Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues.
Rawat DS, Krzysiak AJ, Gibbs RA. Rawat DS, et al. Among authors: gibbs ra. J Org Chem. 2008 Mar 7;73(5):1881-7. doi: 10.1021/jo701725b. Epub 2008 Jan 29. J Org Chem. 2008. PMID: 18225915
Working together: Farnesyl transferase inhibitors and statins block protein prenylation.
Wojtkowiak JW, Gibbs RA, Mattingly RR. Wojtkowiak JW, et al. Among authors: gibbs ra. Mol Cell Pharmacol. 2009 Jan 1;1(1):1-6. doi: 10.4255/mcpharmacol.09.01. Mol Cell Pharmacol. 2009. PMID: 20419048 Free PMC article.
Induction of apoptosis in neurofibromatosis type 1 malignant peripheral nerve sheath tumor cell lines by a combination of novel farnesyl transferase inhibitors and lovastatin.
Wojtkowiak JW, Fouad F, LaLonde DT, Kleinman MD, Gibbs RA, Reiners JJ Jr, Borch RF, Mattingly RR. Wojtkowiak JW, et al. Among authors: gibbs ra. J Pharmacol Exp Ther. 2008 Jul;326(1):1-11. doi: 10.1124/jpet.107.135830. Epub 2008 Mar 26. J Pharmacol Exp Ther. 2008. PMID: 18367665 Free PMC article.
Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase.
Reigard SA, Zahn TJ, Haworth KB, Hicks KA, Fierke CA, Gibbs RA. Reigard SA, et al. Among authors: gibbs ra. Biochemistry. 2005 Aug 23;44(33):11214-23. doi: 10.1021/bi050725l. Biochemistry. 2005. PMID: 16101305
Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues.
Temple KJ, Wright EN, Fierke CA, Gibbs RA. Temple KJ, et al. Among authors: gibbs ra. Org Lett. 2016 Dec 2;18(23):6038-6041. doi: 10.1021/acs.orglett.6b02977. Epub 2016 Nov 14. Org Lett. 2016. PMID: 27934359 Free PMC article.
Synthesis of frame-shifted farnesyl diphosphate analogs.
Placzek AT, Hougland JL, Gibbs RA. Placzek AT, et al. Among authors: gibbs ra. Org Lett. 2012 Aug 17;14(16):4038-41. doi: 10.1021/ol300683r. Epub 2012 Aug 2. Org Lett. 2012. PMID: 22857735 Free PMC article.
New synthetic methodology for the construction of 7-substituted farnesyl diphosphate analogs.
Placzek AT, Gibbs RA. Placzek AT, et al. Among authors: gibbs ra. Org Lett. 2011 Jul 15;13(14):3576-9. doi: 10.1021/ol201069x. Epub 2011 Jun 23. Org Lett. 2011. PMID: 21699139 Free PMC article.
Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity.
Henriksen BS, Anderson JL, Hrycyna CA, Gibbs RA. Henriksen BS, et al. Among authors: gibbs ra. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5080-3. doi: 10.1016/j.bmcl.2005.07.075. Epub 2005 Sep 23. Bioorg Med Chem Lett. 2005. PMID: 16183278 Free PMC article.
Synthesis of 7-substituted farnesyl diphosphate analogues.
Rawat DS, Gibbs RA. Rawat DS, et al. Among authors: gibbs ra. Org Lett. 2002 Sep 5;4(18):3027-30. doi: 10.1021/ol026176i. Org Lett. 2002. PMID: 12201708
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