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A nonallergenic birch pollen allergy vaccine consisting of hepatitis PreS-fused Bet v 1 peptides focuses blocking IgG toward IgE epitopes and shifts immune responses to a tolerogenic and Th1 phenotype.
Marth K, Breyer I, Focke-Tejkl M, Blatt K, Shamji MH, Layhadi J, Gieras A, Swoboda I, Zafred D, Keller W, Valent P, Durham SR, Valenta R. Marth K, et al. Among authors: gieras a. J Immunol. 2013 Apr 1;190(7):3068-78. doi: 10.4049/jimmunol.1202441. Epub 2013 Feb 25. J Immunol. 2013. PMID: 23440415 Free PMC article.
Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet v 1.
Gieras A, Cejka P, Blatt K, Focke-Tejkl M, Linhart B, Flicker S, Stoecklinger A, Marth K, Drescher A, Thalhamer J, Valent P, Majdic O, Valenta R. Gieras A, et al. J Immunol. 2011 May 1;186(9):5333-44. doi: 10.4049/jimmunol.1000804. Epub 2011 Mar 30. J Immunol. 2011. PMID: 21451110 Free article.
Altered IgE epitope presentation: A model for hypoallergenic activity revealed for Bet v 1 trimer.
Campana R, Vrtala S, Maderegger B, Dall'Antonia Y, Zafred D, Blatt K, Herrmann H, Focke-Tejkl M, Swoboda I, Scheiblhofer S, Gieras A, Neubauer A, Keller W, Valent P, Thalhamer J, Spitzauer S, Valenta R. Campana R, et al. Among authors: gieras a. Mol Immunol. 2011 Jan;48(4):431-41. doi: 10.1016/j.molimm.2010.09.016. Epub 2010 Nov 18. Mol Immunol. 2011. PMID: 21093057 Free PMC article.
Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly.
Campana R, Vrtala S, Maderegger B, Jertschin P, Stegfellner G, Swoboda I, Focke-Tejkl M, Blatt K, Gieras A, Zafred D, Neubauer A, Valent P, Keller W, Spitzauer S, Valenta R. Campana R, et al. Among authors: gieras a. J Allergy Clin Immunol. 2010 Nov;126(5):1024-31, 1031.e1-8. doi: 10.1016/j.jaci.2010.05.023. Epub 2010 Jul 16. J Allergy Clin Immunol. 2010. PMID: 20638112
Mast cell-derived proteases control allergic inflammation through cleavage of IgE.
Rauter I, Krauth MT, Westritschnig K, Horak F, Flicker S, Gieras A, Repa A, Balic N, Spitzauer S, Huss-Marp J, Brockow K, Darsow U, Behrendt H, Ring J, Kricek F, Valent P, Valenta R. Rauter I, et al. Among authors: gieras a. J Allergy Clin Immunol. 2008 Jan;121(1):197-202. doi: 10.1016/j.jaci.2007.08.015. Epub 2007 Sep 29. J Allergy Clin Immunol. 2008. PMID: 17904627
18 results