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Genetic links between brain development and brain evolution.
Gilbert SL, Dobyns WB, Lahn BT. Gilbert SL, et al. Nat Rev Genet. 2005 Jul;6(7):581-90. doi: 10.1038/nrg1634. Nat Rev Genet. 2005. PMID: 15951746 Review.
The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.
Mekel-Bobrov N, Posthuma D, Gilbert SL, Lind P, Gosso MF, Luciano M, Harris SE, Bates TC, Polderman TJ, Whalley LJ, Fox H, Starr JM, Evans PD, Montgomery GW, Fernandes C, Heutink P, Martin NG, Boomsma DI, Deary IJ, Wright MJ, de Geus EJ, Lahn BT. Mekel-Bobrov N, et al. Hum Mol Genet. 2007 Mar 15;16(6):600-8. doi: 10.1093/hmg/ddl487. Epub 2007 Jan 12. Hum Mol Genet. 2007. PMID: 17220170
Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates.
Dorus S, Anderson JR, Vallender EJ, Gilbert SL, Zhang L, Chemnick LG, Ryder OA, Li W, Lahn BT. Dorus S, et al. Hum Mol Genet. 2006 Jul 1;15(13):2031-7. doi: 10.1093/hmg/ddl123. Epub 2006 May 10. Hum Mol Genet. 2006. PMID: 16687440
Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice.
Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT. Gilbert SL, et al. Nat Genet. 2006 Feb;38(2):245-50. doi: 10.1038/ng1715. Epub 2005 Dec 25. Nat Genet. 2006. PMID: 16380713
Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.
Mekel-Bobrov N, Gilbert SL, Evans PD, Vallender EJ, Anderson JR, Hudson RR, Tishkoff SA, Lahn BT. Mekel-Bobrov N, et al. Science. 2005 Sep 9;309(5741):1720-2. doi: 10.1126/science.1116815. Science. 2005. PMID: 16151010
Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.
Evans PD, Gilbert SL, Mekel-Bobrov N, Vallender EJ, Anderson JR, Vaez-Azizi LM, Tishkoff SA, Hudson RR, Lahn BT. Evans PD, et al. Science. 2005 Sep 9;309(5741):1717-20. doi: 10.1126/science.1113722. Science. 2005. PMID: 16151009
Accelerated evolution of nervous system genes in the origin of Homo sapiens.
Dorus S, Vallender EJ, Evans PD, Anderson JR, Gilbert SL, Mahowald M, Wyckoff GJ, Malcom CM, Lahn BT. Dorus S, et al. Cell. 2004 Dec 29;119(7):1027-40. doi: 10.1016/j.cell.2004.11.040. Cell. 2004. PMID: 15620360
Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.
Evans PD, Anderson JR, Vallender EJ, Gilbert SL, Malcom CM, Dorus S, Lahn BT. Evans PD, et al. Hum Mol Genet. 2004 Mar 1;13(5):489-94. doi: 10.1093/hmg/ddh055. Epub 2004 Jan 13. Hum Mol Genet. 2004. PMID: 14722158
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