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Sequence alignment visualization in HTML5 without Java.
Gille C, Birgit W, Gille A. Gille C, et al. Bioinformatics. 2014 Jan 1;30(1):121-2. doi: 10.1093/bioinformatics/btt614. Epub 2013 Nov 21. Bioinformatics. 2014. PMID: 24273246
The server side script interpreter can perform all tasks like (i) sequence retrieval, (ii) alignment computation, (iii) rendering, (iv) identification of a homologous structural models and (v) communication with BioDAS-servers. ...
The server side script interpreter can perform all tasks like (i) sequence retrieval, (ii) alignment computation, (iii) rendering, (iv) iden …
Alignment-Annotator web server: rendering and annotating sequence alignments.
Gille C, Fähling M, Weyand B, Wieland T, Gille A. Gille C, et al. Nucleic Acids Res. 2014 Jul;42(Web Server issue):W3-6. doi: 10.1093/nar/gku400. Epub 2014 May 9. Nucleic Acids Res. 2014. PMID: 24813445 Free PMC article.
Alignment-Annotator is a novel web service designed to generate interactive views of annotated nucleotide and amino acid sequence alignments (i) de novo and (ii) embedded in other software. ...Some edits take immediate effect while others require server interaction and may …
Alignment-Annotator is a novel web service designed to generate interactive views of annotated nucleotide and amino acid sequence ali …
Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate.
Hübner M, Dixit A, Mou TC, Lushington GH, Pinto C, Gille A, Geduhn J, König B, Sprang SR, Seifert R. Hübner M, et al. Mol Pharmacol. 2011 Jul;80(1):87-96. doi: 10.1124/mol.111.071894. Epub 2011 Apr 15. Mol Pharmacol. 2011. PMID: 21498658 Free PMC article.
MANT-ITP was a considerably more potent inhibitor of the purified catalytic domains VC1 and IIC2 of mAC than MANT-GTP (K(i), 0.7 versus 18 nM). ...The higher affinity of MANT-ITP to mAC compared with MANT-GTP is probably due to fewer stereochemical constraints upon the nuc …
MANT-ITP was a considerably more potent inhibitor of the purified catalytic domains VC1 and IIC2 of mAC than MANT-GTP (K(i), 0.7 vers …
Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.
Nøhr MK, Egerod KL, Christiansen SH, Gille A, Offermanns S, Schwartz TW, Møller M. Nøhr MK, et al. Neuroscience. 2015 Apr 2;290:126-37. doi: 10.1016/j.neuroscience.2015.01.040. Epub 2015 Jan 28. Neuroscience. 2015. PMID: 25637492
G-protein-coupled receptor 41 (GPR41) also called free fatty acid receptor 3 (FFAR3) is a Gαi-coupled receptor activated by short-chain fatty acids (SCFAs) mainly produced from dietary complex carbohydrate fibers in the large intestine as products of fermentation by microb …
G-protein-coupled receptor 41 (GPR41) also called free fatty acid receptor 3 (FFAR3) is a Gαi-coupled receptor activated by short-cha …
Nicotinic acid: pharmacological effects and mechanisms of action.
Gille A, Bodor ET, Ahmed K, Offermanns S. Gille A, et al. Annu Rev Pharmacol Toxicol. 2008;48:79-106. doi: 10.1146/annurev.pharmtox.48.113006.094746. Annu Rev Pharmacol Toxicol. 2008. PMID: 17705685 Review.
The clinical use of nicotinic acid is, however, hindered by harmless but unpleasant side effects, especially by a strong cutaneous vasodilation called flushing. The recent discovery of the G protein-coupled receptor GPR109A (HM74A or PUMA-G) as a receptor for nicoti …
The clinical use of nicotinic acid is, however, hindered by harmless but unpleasant side effects, especially by a strong cutaneous va …
Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases.
Pinto C, Lushington GH, Richter M, Gille A, Geduhn J, König B, Mou TC, Sprang SR, Seifert R. Pinto C, et al. Biochem Pharmacol. 2011 Aug 15;82(4):358-70. doi: 10.1016/j.bcp.2011.05.010. Epub 2011 May 18. Biochem Pharmacol. 2011. PMID: 21620805 Free PMC article.
Omission of a hydroxyl group at the 2' or 3'-position reduced inhibitor potency as did introduction of a γ-thiophosphate group or omission of the γ-phosphate group. ...Overall, ACs possess a broad base-specificity with no preference for the "cognate" base ade …
Omission of a hydroxyl group at the 2' or 3'-position reduced inhibitor potency as did introduction of a γ-thiophosphate group …
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates.
Suryanarayana S, Göttle M, Hübner M, Gille A, Mou TC, Sprang SR, Richter M, Seifert R. Suryanarayana S, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):687-95. doi: 10.1124/jpet.109.155432. Epub 2009 Jun 3. J Pharmacol Exp Ther. 2009. PMID: 19494187 Free PMC article.
Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP and play a key role in signal transduction. ...Interaction of VC1:IIC2 with TNP-NDPs and TNP-NTPs resulted in large fluorescence increases that were differentially reduced by a wat …
Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP and play a key role in signal transduction. ... …
Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs.
Pinto C, Hübner M, Gille A, Richter M, Mou TC, Sprang SR, Seifert R. Pinto C, et al. Biochem Pharmacol. 2009 Jul 1;78(1):62-9. doi: 10.1016/j.bcp.2009.03.023. Epub 2009 Apr 2. Biochem Pharmacol. 2009. PMID: 19447224 Free PMC article.
The C(1)-OH group forms a hydrogen bond with the backbone oxygen of Val506 of the C1 catalytic subunit of AC (isoform V numbering). ...In the second and yet poorly understood step, diterpenes that form a hydrogen bond between C(1)-OH and Val506 promote a conf …
The C(1)-OH group forms a hydrogen bond with the backbone oxygen of Val506 of the C1 catalytic subunit of AC (isoform V numbering). . …
Characterization of mouse heart adenylyl cyclase.
Göttle M, Geduhn J, König B, Gille A, Höcherl K, Seifert R. Göttle M, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1156-65. doi: 10.1124/jpet.109.150953. Epub 2009 Mar 23. J Pharmacol Exp Ther. 2009. PMID: 19307450
Unfortunately, a limitation of our study is the fact that immunologically and biochemically, AC5 and AC6 are quite similar, although they have different roles in heart. ...
Unfortunately, a limitation of our study is the fact that immunologically and biochemically, AC5 and AC6 are quite similar, although …
Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.
Gille A, Lushington GH, Mou TC, Doughty MB, Johnson RA, Seifert R. Gille A, et al. J Biol Chem. 2004 May 7;279(19):19955-69. doi: 10.1074/jbc.M312560200. Epub 2004 Feb 23. J Biol Chem. 2004. PMID: 14981084
Mammals express nine membranous adenylyl cyclase isoforms (ACs 1-9), a structurally related soluble guanylyl cyclase (sGC) and a soluble AC (sAC). ...N-Methylanthraniloyl (MANT)-GTP inhibited C1.C2 with a K(i) of 4.2 nm. Phe-889 and Ile-940 of C2 mediate hydr …
Mammals express nine membranous adenylyl cyclase isoforms (ACs 1-9), a structurally related soluble guanylyl cyclase (sGC) and a
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