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Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey.
Hohlbaum AM, Gille H, Trentmann S, Kolodziejczyk M, Rattenstetter B, Laarakkers CM, Katzmann G, Christian HJ, Andersen N, Allersdorfer A, Olwill SA, Meibohm B, Audoly LP, Swinkels DW, van Swelm RPL. Hohlbaum AM, et al. Among authors: gille h. Br J Pharmacol. 2018 Apr;175(7):1054-1065. doi: 10.1111/bph.14143. Epub 2018 Feb 23. Br J Pharmacol. 2018. PMID: 29329501 Free PMC article.
An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies.
Schönfeld D, Matschiner G, Chatwell L, Trentmann S, Gille H, Hülsmeyer M, Brown N, Kaye PM, Schlehuber S, Hohlbaum AM, Skerra A. Schönfeld D, et al. Among authors: gille h. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8198-203. doi: 10.1073/pnas.0813399106. Epub 2009 May 5. Proc Natl Acad Sci U S A. 2009. PMID: 19416843 Free PMC article.
A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activity.
Olwill SA, Joffroy C, Gille H, Vigna E, Matschiner G, Allersdorfer A, Lunde BM, Jaworski J, Burrows JF, Chiriaco C, Christian HJ, Hülsmeyer M, Trentmann S, Jensen K, Hohlbaum AM, Audoly L. Olwill SA, et al. Among authors: gille h. Mol Cancer Ther. 2013 Nov;12(11):2459-71. doi: 10.1158/1535-7163.MCT-13-0318. Epub 2013 Sep 3. Mol Cancer Ther. 2013. PMID: 24002935
Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma.
Matschiner G, Fitzgerald MF, Moebius U, Hohlbaum AM, Gille H, Jensen K, Kirchfeld K, Rattenstetter B, Laforge A, Bel Aiba RS, Ciccotosto J, Nyugen H, Foster ML, Snouwaert JN, Nguyen M, Koller BH, Matis L, Anderson GP, Olwill SA. Matschiner G, et al. Among authors: gille h. J Allergy Clin Immunol. 2023 Apr;151(4):966-975. doi: 10.1016/j.jaci.2022.12.815. Epub 2022 Dec 30. J Allergy Clin Immunol. 2023. PMID: 36592703 Free article.
Development of secreted proteins as biotherapeutic agents.
Bonin-Debs AL, Boche I, Gille H, Brinkmann U. Bonin-Debs AL, et al. Among authors: gille h. Expert Opin Biol Ther. 2004 Apr;4(4):551-8. doi: 10.1517/14712598.4.4.551. Expert Opin Biol Ther. 2004. PMID: 15102604 Review.
89 results