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Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.
Lambillotte C, Gilon P, Henquin JC. Lambillotte C, et al. J Clin Invest. 1997 Feb 1;99(3):414-23. doi: 10.1172/JCI119175. J Clin Invest. 1997. PMID: 9022074 Free PMC article.
This inhibition could not be ascribed to a lowering of insulin stores (higher in dexamethasone-treated islets), to an alteration of glucose metabolism (glucose oxidation and NAD(P)H changes were unaffected), or to a lesser rise of cytoplasmic Ca2+ in beta cells (only the f …
This inhibition could not be ascribed to a lowering of insulin stores (higher in dexamethasone-treated islets), to an alteration of glucose …
Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell.
Gilon P, Henquin JC. Gilon P, et al. J Biol Chem. 1992 Oct 15;267(29):20713-20. J Biol Chem. 1992. PMID: 1400388
Glucose (15 mM) sequentially triggered an increase in NAD(P)H fluorescence, a depolarization with electrical activity, and a rise in Ca2+i. The change in NAD(P)H was monophasic and regular, whereas the changes in membrane potential and Ca2+i were multiphasic, with s …
Glucose (15 mM) sequentially triggered an increase in NAD(P)H fluorescence, a depolarization with electrical activity, and a rise in …
Vanadate stimulation of insulin release in normal mouse islets.
Zhang AQ, Gao ZY, Gilon P, Nenquin M, Drews G, Henquin JC. Zhang AQ, et al. J Biol Chem. 1991 Nov 15;266(32):21649-56. J Biol Chem. 1991. PMID: 1657974
Muscarinic stimulation exerts both stimulatory and inhibitory effects on the concentration of cytoplasmic Ca2+ in the electrically excitable pancreatic B-cell.
Gilon P, Nenquin M, Henquin JC. Gilon P, et al. Biochem J. 1995 Oct 1;311 ( Pt 1)(Pt 1):259-67. doi: 10.1042/bj3110259. Biochem J. 1995. PMID: 7575463 Free PMC article.
Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets.
Jonas JC, Plant TD, Gilon P, Detimary P, Nenquin M, Henquin JC. Jonas JC, et al. Br J Pharmacol. 1995 Feb;114(4):872-80. doi: 10.1111/j.1476-5381.1995.tb13285.x. Br J Pharmacol. 1995. PMID: 7773549 Free PMC article.
Multisite control of insulin release by glucose.
Henquin JC, Gembal M, Detimary P, Gao ZY, Warnotte C, Gilon P. Henquin JC, et al. Diabete Metab. 1994 Mar-Apr;20(2):132-7. Diabete Metab. 1994. PMID: 7805950 Review.
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