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FGF21-based pharmacotherapy--potential utility for metabolic disorders.
Gimeno RE, Moller DE. Gimeno RE, et al. Trends Endocrinol Metab. 2014 Jun;25(6):303-11. doi: 10.1016/j.tem.2014.03.001. Epub 2014 Apr 5. Trends Endocrinol Metab. 2014. PMID: 24709036 Review.
FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency.
Dollet L, Levrel C, Coskun T, Le Lay S, Le May C, Ayer A, Venara Q, Adams AC, Gimeno RE, Magré J, Cariou B, Prieur X. Dollet L, et al. Among authors: gimeno re. Diabetes. 2016 Nov;65(11):3410-3417. doi: 10.2337/db16-0327. Epub 2016 Aug 23. Diabetes. 2016. PMID: 27554469 Free article.
Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity.
Samms RJ, Cheng CC, Kharitonenkov A, Gimeno RE, Adams AC. Samms RJ, et al. Among authors: gimeno re. Endocrinology. 2016 Apr;157(4):1467-80. doi: 10.1210/en.2015-1722. Epub 2016 Feb 22. Endocrinology. 2016. PMID: 26901091
The Sweetest Thing: Regulation of Macronutrient Preference by FGF21.
Adams AC, Gimeno RE. Adams AC, et al. Among authors: gimeno re. Cell Metab. 2016 Feb 9;23(2):227-8. doi: 10.1016/j.cmet.2016.01.013. Cell Metab. 2016. PMID: 26863484 Free article.
Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.
Samms RJ, Smith DP, Cheng CC, Antonellis PP, Perfield JW 2nd, Kharitonenkov A, Gimeno RE, Adams AC. Samms RJ, et al. Among authors: gimeno re. Cell Rep. 2015 May 19;11(7):991-9. doi: 10.1016/j.celrep.2015.04.046. Epub 2015 May 5. Cell Rep. 2015. PMID: 25956583 Free article.
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue.
Adams AC, Yang C, Coskun T, Cheng CC, Gimeno RE, Luo Y, Kharitonenkov A. Adams AC, et al. Among authors: gimeno re. Mol Metab. 2012 Aug 28;2(1):31-7. doi: 10.1016/j.molmet.2012.08.007. eCollection 2012. Mol Metab. 2012. PMID: 24024127 Free PMC article.
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. Emmerson PJ, et al. Among authors: gimeno re. Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846098
LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.
Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, Kuchibhotla U, Moyers JS, Benson CT, Gimeno RE, D'Alessio DA, Haupt A. Coskun T, et al. Among authors: gimeno re. Mol Metab. 2018 Dec;18:3-14. doi: 10.1016/j.molmet.2018.09.009. Epub 2018 Oct 3. Mol Metab. 2018. PMID: 30473097 Free PMC article. Clinical Trial.
Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity.
Cao J, Perez S, Goodwin B, Lin Q, Peng H, Qadri A, Zhou Y, Clark RW, Perreault M, Tobin JF, Gimeno RE. Cao J, et al. Among authors: gimeno re. Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1176-87. doi: 10.1152/ajpendo.00666.2013. Epub 2014 Apr 8. Am J Physiol Endocrinol Metab. 2014. PMID: 24714397
Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial.
Frias JP, Nauck MA, Van J, Kutner ME, Cui X, Benson C, Urva S, Gimeno RE, Milicevic Z, Robins D, Haupt A. Frias JP, et al. Among authors: gimeno re. Lancet. 2018 Nov 17;392(10160):2180-2193. doi: 10.1016/S0140-6736(18)32260-8. Epub 2018 Oct 4. Lancet. 2018. PMID: 30293770 Clinical Trial.
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