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The following terms were not found in PubMed: Rh1+interleukin-1beta+intervertebral, degeneration+nuclear, kappa-B+nucleus
Page 1
Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration.
Yang YH, Gu XP, Hu H, Hu B, Wan XL, Gu ZP, Zhong SJ. Yang YH, et al. J Orthop Surg Res. 2022 Dec 20;17(1):555. doi: 10.1186/s13018-022-03443-4. J Orthop Surg Res. 2022. PMID: 36539815 Free PMC article.
METHODS: The rat model of IDD and nucleus pulposus (NP) experimental groups treated with ginsenoside Rg1 was constructed for investing the role of ginsenoside Rg1 in IDD rats. ...Ginsenoside Rg1 had a significant inhibitory effect on the secretion leve …
METHODS: The rat model of IDD and nucleus pulposus (NP) experimental groups treated with ginsenoside Rg1 was constructed for i …
Does ginsenoside Rg1 promote intervertebral disc repair? An experimental study insights into ferroptosis mechanism.
Gong D, Xia F, Wang F, Tong X, Yang Q, Shen K, Sun B, Chen N, Lu Z. Gong D, et al. J Transl Med. 2025 Nov 6;23(1):1231. doi: 10.1186/s12967-025-07047-4. J Transl Med. 2025. PMID: 41199365 Free PMC article.
Additionally, an Hydrogen peroxide (H(2)O(2))-induced degeneration model of nucleus pulposus cells (NP cells) was used to evaluate the efficacy of ginsenoside Rg1 in alleviating IVDD in vitro. ...Treatment with ML385 attenuated the ginsenoside R …
Additionally, an Hydrogen peroxide (H(2)O(2))-induced degeneration model of nucleus pulposus cells (NP cells) was used …
Notoginsenoside R1 suppresses inflammatory response and the pyroptosis of nucleus pulposus cells via inactivating NF-kappaB/NLRP3 pathways.
Tang K, Su W, Huang C, Wu Y, Wu X, Lu H. Tang K, et al. Int Immunopharmacol. 2021 Dec;101(Pt B):107866. doi: 10.1016/j.intimp.2021.107866. Epub 2021 Sep 26. Int Immunopharmacol. 2021. PMID: 34588155
Intervertebral disc degeneration (IVDD) is the main cause of low back pain. Notoginsenoside R1 (NR1) is widely applied in the treatment of bone disorders, including IVDD. ...Additionally, NR1 inactivated NF-kappaB/NLRP3 pathways, improved cellular functions of nucleus p …
Intervertebral disc degeneration (IVDD) is the main cause of low back pain. Notoginsenoside R1 (NR1) is widely applied in the treatme …
Ginsenoside Rg1 relieves rat intervertebral disc degeneration and inhibits IL-1beta-induced nucleus pulposus cell apoptosis and inflammation via NF-kappaB signaling pathway.
Yu L, Hao YJ, Ren ZN, Zhu GD, Zhou WW, Lian X, Wu XJ. Yu L, et al. In Vitro Cell Dev Biol Anim. 2024 Mar;60(3):287-299. doi: 10.1007/s11626-024-00883-6. Epub 2024 Mar 14. In Vitro Cell Dev Biol Anim. 2024. PMID: 38485818 Free PMC article.
The study aimed to investigate the effect of ginsenoside Rg1 on intervertebral disc degeneration (IVDD) in rats and IL-1beta-induced nucleus pulposus (NP) cells, and explore its underlying mechanism. ...Ginsenoside Rg1 alleviated IVDD in rats an …
The study aimed to investigate the effect of ginsenoside Rg1 on intervertebral disc degeneration (IVDD) in rats and IL-1beta-i …
Targeting Ferroptosis With Ginsenoside Rg3 Alleviates Intervertebral Disc Degeneration.
Xu W, Geng F, Zhang K, Wang Y. Xu W, et al. Orthop Surg. 2025 Oct;17(10):2960-2972. doi: 10.1111/os.70150. Epub 2025 Aug 25. Orthop Surg. 2025. PMID: 40852892 Free PMC article.
OBJECTIVE: Intervertebral disc degeneration (IVDD) has been closely associated with ferroptosis in nucleus pulposus cells (NPCs), the underlying regulatory mechanisms and therapeutic strategies remain poorly defined. ...Therapeutic efficacy was evaluated by M …
OBJECTIVE: Intervertebral disc degeneration (IVDD) has been closely associated with ferroptosis in nucleus pulposus cells …
Ginsenoside-Rh2 Alleviates Pyroptosis of Nucleus Pulposus Cells by Activating Autophagy via HIF-1alpha to Retard the Progression of Intervertebral Disc Degeneration.
Xuan J, Chen J, Liu H, Chen Y, Zhang Z. Xuan J, et al. J Cell Physiol. 2026 May;241(5):e70189. doi: 10.1002/jcp.70189. J Cell Physiol. 2026. PMID: 42116708
In the pathogenesis of intervertebral disc degeneration (IVDD), nucleus pulposus (NP) cell dysfunction is a pivotal factor, specifically manifested as extracellular matrix degradation, impaired autophagy, and pyroptosis. Ginsenoside-Rh2 (GRh2) possesse …
In the pathogenesis of intervertebral disc degeneration (IVDD), nucleus pulposus (NP) cell dysfunction is a pivotal factor …
Ginsenoside Rd inhibits IL-1beta-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination.
Zhang WJ, Liu Y, Wei JS, Wu YL. Zhang WJ, et al. Braz J Med Biol Res. 2019;52(9):e8525. doi: 10.1590/1414-431X20198525. Epub 2019 Aug 12. Braz J Med Biol Res. 2019. Retraction in: Braz J Med Biol Res. 2019 Dec 05;52(12):e8525retraction. doi: 10.1590/1414-431X20198525retraction. PMID: 31411316 Free PMC article. Retracted.
Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. ...In this study, chondrocytes were isolated from the nucleus …
Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondroc …