α-spinasterol isolated from Achyranthes aspera L. ameliorates inflammation via NF-κB and Nrf2/HO-1 pathways.
Zeng Q, Xiao W, Zhang H, Liu W, Wang X, Li Z, Han Y, Wang Z, Li S, Yang J, Ouyang W.
Zeng Q, et al.
Sci Rep. 2025 Feb 17;15(1):5723. doi: 10.1038/s41598-025-90022-2.
Sci Rep. 2025.
PMID: 39962315
Free PMC article.
Futhermore, in the LPS-induced RAW264.7 cells inflammation model, alpha-spinasterol significantly reduced the levels of cytokines such as IL-6, PGE2 and TNF-alpha, inhibited the expression of COX-2, 5-LOX, p-IKKbeta, p-NFkappaB and p-IkBalpha proteins, and promoted …
Futhermore, in the LPS-induced RAW264.7 cells inflammation model, alpha-spinasterol significantly reduced the levels of cytoki …