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A new mesalazine gel enema in the treatment of left-sided ulcerative colitis: a randomized controlled multicentre trial
Gionchetti P, et al. Aliment Pharmacol Ther 1999 - Clinical Trial. PMID 10102972
RESULTS: After 4 weeks of treatment, clinical remission was achieved by 76% of mesalazine gel enema-treated patients and 69% of patients treated with mesalazine foam enema (P = 0.608). ...Patients in the foam group had significantly more difficulty in retention (25% vs. 6%, P < 0.05), abdominal bloating (50% vs. 26%, P < 0.005) and discomfort during administration (48% vs. 26%, P < 0.05). ...
RESULTS: After 4 weeks of treatment, clinical remission was achieved by 76% of mesalazine gel enema-treated patients and 69% of patients tre …
Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis
Venturi A, et al. Aliment Pharmacol Ther 1999 - Clinical Trial. Among authors: Gionchetti P. PMID 10468688
RESULTS: Faecal concentrations of Streptococcus salivarius ssp. thermophilus, lactobacilli and bifidobacteria increased significantly in all patients, compared to their basal level, from the 20th day of treatment (P<0.05) and remained stable throughout the study. Concentrations of Bacteroides, clostridia, coliforms, total aerobic and anaerobic bacteria did not change significantly during treatment (P = N.S.). ...
RESULTS: Faecal concentrations of Streptococcus salivarius ssp. thermophilus, lactobacilli and bifidobacteria increased significantly in all …
Oral beclomethasone dipropionate in patients with mild to moderate ulcerative colitis: a dose-finding study
Rizzello F, et al. Adv Ther 2001 - Clinical Trial. Among authors: Gionchetti P. PMID 11841196
Significant improvement from baseline occurred in most signs and symptoms of UC, particularly stool frequency, rectal bleeding, and mucus in the stool (P<.01). ...
Significant improvement from baseline occurred in most signs and symptoms of UC, particularly stool frequency, rectal bleeding, and mucus in …
Oral beclometasone dipropionate in the treatment of active ulcerative colitis: a double-blind placebo-controlled study
Rizzello F, et al. Aliment Pharmacol Ther 2002 - Clinical Trial. Among authors: Gionchetti P. PMID 12030952
DAI score was lower in the BDP group than in the placebo group (P = 0.014), with more patients in clinical remission in the BDP group (58.6% vs. 34.4%, P = 0.008). Serum cortisol levels significantly decreased in BDP group vs. baseline (P = 0.002), but without signs of pituitary-adrenal function depletion. ...
DAI score was lower in the BDP group than in the placebo group (P = 0.014), with more patients in clinical remission in the BDP group …
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