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Role of the retinoblastoma family in gynecological cancer.
Sanseverino F, Torricelli M, Petraglia F, Giordano A. Sanseverino F, et al. Cancer Biol Ther. 2003 Nov-Dec;2(6):636-41. Cancer Biol Ther. 2003. PMID: 14688467 Review.
The cell cycle consists of a series of events that regulate cell life. The regulation and coordination result from a combination of several signals from different regulatory pathways which are activated in response to the presence of the right stimuli. Tumor suppres …
The cell cycle consists of a series of events that regulate cell life. The regulation and coordination result from a combinati …
Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.
Mayol X, Graña X, Baldi A, Sang N, Hu Q, Giordano A. Mayol X, et al. Oncogene. 1993 Sep;8(9):2561-6. Oncogene. 1993. PMID: 8361765
The product of the retinoblastoma tumor suppressor gene (pRb) and p107 share a high degree of structural homology in the pocket region, which is thought to play a primary role in the function of these proteins. It is conceivable that there exists a larger fam …
The product of the retinoblastoma tumor suppressor gene (pRb) and p107 share a high degree of structural homology in the pocket regio …
The retinoblastoma gene: its role in cell cycle and cancer.
Giordano A, Kaiser HE. Giordano A, et al. In Vivo. 1996 Mar-Apr;10(2):223-7. In Vivo. 1996. PMID: 8744804 Review.
However, it is difficult to rationalize the expression of pRb in a wide range of tissues with the fact that only limited cell types are susceptible to tumor formation when Rb expression is lost. Recent characterizations of Rb-associated proteins may provide some clues as t …
However, it is difficult to rationalize the expression of pRb in a wide range of tissues with the fact that only limited cell types a …
The retinoblastoma gene family and its role in proliferation, differentiation and development.
De Luca A, Esposito V, Baldi A, Giordano A. De Luca A, et al. Histol Histopathol. 1996 Oct;11(4):1029-34. Histol Histopathol. 1996. PMID: 8930645 Review.
These three proteins share many structural and functional features and play a fundamental role in growth control. Intense investigation of these proteins has identified a series of similar cell-cycle regulators and transcription factors with which they interact. ...
These three proteins share many structural and functional features and play a fundamental role in growth control. Intense investigati …
Molecular cloning, expression, and developmental characterization of the murine retinoblastoma-related gene Rb2/p130.
Pertile P, Baldi A, De Luca A, Bagella L, Virgilio L, Pisano MM, Giordano A. Pertile P, et al. Cell Growth Differ. 1995 Dec;6(12):1659-64. Cell Growth Differ. 1995. PMID: 9019172
The product of the retinoblastoma-related human gene Rb2/p130 is highly homologous with the product of the retinoblastoma tumor suppressor gene (pRb) and Rb-related p107. this homology is shared mainly in the pocket domain, a region that seems to play a key role in …
The product of the retinoblastoma-related human gene Rb2/p130 is highly homologous with the product of the retinoblastoma tumor suppressor g …
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.
Esposito V, Baldi A, De Luca A, Groger AM, Loda M, Giordano GG, Caputi M, Baldi F, Pagano M, Giordano A. Esposito V, et al. Cancer Res. 1997 Aug 15;57(16):3381-5. Cancer Res. 1997. PMID: 9270000
Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. ...When we evaluated the outcome of the patients in relationship to p27 expression, w …
Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibito …
Retinoblastoma-related protein pRb2/p130 and its binding to the B-myb promoter increase during human neuroblastoma differentiation.
Raschellà G, Tanno B, Bonetto F, Amendola R, Battista T, De Luca A, Giordano A, Paggi MG. Raschellà G, et al. J Cell Biochem. 1997 Dec 1;67(3):297-303. J Cell Biochem. 1997. PMID: 9361185
Neuroblastoma cells can undergo neural differentiation upon treatment with a variety of chemical inducers and growth factors. ...Interestingly, E2F4, a preferential partner of p107 and pRb2/p130, was upregulated and underwent changes in cellular localization during …
Neuroblastoma cells can undergo neural differentiation upon treatment with a variety of chemical inducers and growth factors. ...Inte …
Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation.
Giani C, Casalini P, Pupa SM, De Vecchi R, Ardini E, Colnaghi MI, Giordano A, Ménard S. Giani C, et al. Oncogene. 1998 Jul 30;17(4):425-32. doi: 10.1038/sj.onc.1201954. Oncogene. 1998. PMID: 9696035
Unexpectedly, colony formation assay revealed a reduction in the number and size of colonies as compared with mock-transfected cells. ...By contrast, two c-erbB-2-transfected clones grown in complete medium showed a reduced proliferation rate despite the activation …
Unexpectedly, colony formation assay revealed a reduction in the number and size of colonies as compared with mock-transfected cells. …
Retinoblastoma-related protein pRb2/p130 and suppression of tumor growth in vivo.
Howard CM, Claudio PP, Gallia GL, Gordon J, Giordano GG, Hauck WW, Khalili K, Giordano A. Howard CM, et al. J Natl Cancer Inst. 1998 Oct 7;90(19):1451-60. doi: 10.1093/jnci/90.19.1451. J Natl Cancer Inst. 1998. PMID: 9776410
A variety of indirect evidence suggests that another member of the retinoblastoma gene family, RB2/p130, is also a tumor suppressor gene. ...CONCLUSION: Our findings support the hypothesis that RB2/p130 is a tumor suppressor gene....
A variety of indirect evidence suggests that another member of the retinoblastoma gene family, RB2/p130, is also a tumor suppr
Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer.
Baldi A, Esposito V, De Luca A, Howard CM, Mazzarella G, Baldi F, Caputi M, Giordano A. Baldi A, et al. Clin Cancer Res. 1996 Jul;2(7):1239-45. Clin Cancer Res. 1996. PMID: 9816293
These three proteins share many structural and functional features and play a fundamental role in growth control. Using immunocytochemical techniques, we evaluated a variety of lung tumor specimens for the expression of this family of proteins and compared protein e …
These three proteins share many structural and functional features and play a fundamental role in growth control. Using immunocytoche …
2,184 results
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