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Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.
Lin L, Betsuyaku T, Heimbach L, Li N, Rubenstein D, Shapiro SD, An L, Giudice GJ, Diaz LA, Senior RM, Liu Z. Lin L, et al. Among authors: Giudice GJ. Matrix Biol. 2012 Jan;31(1):38-44. doi: 10.1016/j.matbio.2011.09.003. Epub 2011 Sep 25. Matrix Biol. 2012. PMID: 21979170 Free PMC article.
Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model.
Liu Z, Sui W, Zhao M, Li Z, Li N, Thresher R, Giudice GJ, Fairley JA, Sitaru C, Zillikens D, Ning G, Marinkovich MP, Diaz LA. Liu Z, et al. Among authors: Giudice GJ. J Autoimmun. 2008 Dec;31(4):331-8. doi: 10.1016/j.jaut.2008.08.009. Epub 2008 Oct 14. J Autoimmun. 2008. PMID: 18922680 Free PMC article.
A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice.
Fairley JA, Burnett CT, Fu CL, Larson DL, Fleming MG, Giudice GJ. Fairley JA, et al. Among authors: Giudice GJ. J Invest Dermatol. 2007 Nov;127(11):2605-11. doi: 10.1038/sj.jid.5700958. Epub 2007 Jul 5. J Invest Dermatol. 2007. PMID: 17611576 Free article.
The NC16A domain of collagen XVII plays a role in triple helix assembly and stability.
Van den Bergh F, Fu CL, Olague-Marchan M, Giudice GJ. Van den Bergh F, et al. Among authors: Giudice GJ. Biochem Biophys Res Commun. 2006 Dec 1;350(4):1032-7. doi: 10.1016/j.bbrc.2006.09.147. Epub 2006 Oct 5. Biochem Biophys Res Commun. 2006. PMID: 17045967 Free PMC article.
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