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Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human.
Giustina A, Veldhuis JD. Giustina A, et al. Endocr Rev. 1998 Dec;19(6):717-97. doi: 10.1210/edrv.19.6.0353. Endocr Rev. 1998. PMID: 9861545 Review.
Understanding the dynamic neuroendocrine mechanisms that direct the pulsatile secretion of this fundamental growth-promoting and metabolic hormone remains a critical goal, the realization of which is challenged by the exponentially accumulating matrix of experimental and c …
Understanding the dynamic neuroendocrine mechanisms that direct the pulsatile secretion of this fundamental growth-promoting and metabolic h …
Growth hormone receptor isoforms and fracture risk in adult-onset growth hormone-deficient patients.
Mormando M, Chiloiro S, Bianchi A, Giampietro A, Angelini F, Tartaglione L, Nasto L, Milardi D, Formenti AM, Giustina A, De Marinis L. Mormando M, et al. Clin Endocrinol (Oxf). 2016 Nov;85(5):717-724. doi: 10.1111/cen.13161. Epub 2016 Aug 22. Clin Endocrinol (Oxf). 2016. PMID: 27437620
Two GH receptor isoforms (GHRi) have been identified: they differ for the presence/absence of a protein fragment encoded by exon 3 of GHR gene. ...This polymorphism confers a higher sensitivity to endogenous GH and to recombinant human GH (rhGH); its effect on bone …
Two GH receptor isoforms (GHRi) have been identified: they differ for the presence/absence of a protein fragment encoded by exon 3 of …
Prognostic significance of the Ki-67 labeling index in growth hormone-secreting pituitary adenomas.
Fusco A, Zatelli MC, Bianchi A, Cimino V, Tilaro L, Veltri F, Angelini F, Lauriola L, Vellone V, Doglietto F, Ambrosio MR, Maira G, Giustina A, degli Uberti EC, Pontecorvi A, De Marinis L. Fusco A, et al. J Clin Endocrinol Metab. 2008 Jul;93(7):2746-50. doi: 10.1210/jc.2008-0126. Epub 2008 May 6. J Clin Endocrinol Metab. 2008. PMID: 18460561
CONTEXT: Ki-67 is a marker of proliferation activity associated with invasiveness and prognosis in human tumors. OBJECTIVE: The aim of the study was to evaluate the Ki-67 index prognostic relevance in a group of acromegalic patients who underwent transsphenoidal sur …
CONTEXT: Ki-67 is a marker of proliferation activity associated with invasiveness and prognosis in human tumors. OBJECTIVE: The aim o …
Preoperative growth hormone response to thyrotropin-releasing hormone and oral glucose tolerance test in acromegaly: a retrospective evaluation of 50 patients.
De Marinis L, Mancini A, Bianchi A, Gentilella R, Valle D, Giampietro A, Zuppi P, Anile C, Maira G, Giustina A. De Marinis L, et al. Metabolism. 2002 May;51(5):616-21. doi: 10.1053/meta.2002.32017. Metabolism. 2002. PMID: 11979395
Preoperatively, "controlled" patients (n = 29) had a GH paradoxical response to TRH (n = 28) and an unresponsiveness to OGTT (n = 29); 23 of them belonged to the I and II classes. Only 5 poorly controlled patients (n = 21) showed a preoperative paradoxical response …
Preoperatively, "controlled" patients (n = 29) had a GH paradoxical response to TRH (n = 28) and an unresponsiveness to OGTT (n = 29) …
Role of food intake in the modulation of hexarelin-induced growth hormone release in normal human subjects.
De Marinis L, Mancini A, Valle D, Izzi D, Bianchi A, Gentilella R, Giampietro A, Desenzani P, Giustina A. De Marinis L, et al. Horm Metab Res. 2000 Apr;32(4):152-6. doi: 10.1055/s-2007-978611. Horm Metab Res. 2000. PMID: 10824712 Clinical Trial.
Hexarelin (HEX) is a new synthetic analog of the Growth Hormone releasing peptides and is stronger than GHRH in releasing GH in vivo. ...Our data confirm that HEX is much more powerful than GHRH in inducing GH release in humans, both in the fasting state (GH-AUC: 3010 +/- …
Hexarelin (HEX) is a new synthetic analog of the Growth Hormone releasing peptides and is stronger than GHRH in releasing GH in vivo. …
Exercise-induced microalbuminuria in patients with active acromegaly: acute effects of slow-release lanreotide, a long-acting somatostatin analog.
Manelli F, Bossoni S, Burattin A, Doga M, Solerte SB, Romanelli G, Giustina A. Manelli F, et al. Metabolism. 2000 May;49(5):634-9. doi: 10.1016/s0026-0495(00)80040-2. Metabolism. 2000. PMID: 10831175
The aim of our study was to evaluate the acute short-term effects of slow-release lanreotide (SR-L), a long-acting somatostatin analog, on UAE and alpha1-microglobulinuria (A-1-M), a marker of renal tubular damage, at rest and after exercise in 7 normotensive …
The aim of our study was to evaluate the acute short-term effects of slow-release lanreotide (SR-L), a long-acting somatostatin analo …
New medical therapies of acromegaly.
Maffezzoni F, Frara S, Doga M, Mazziotti G, Giustina A. Maffezzoni F, et al. Growth Horm IGF Res. 2016 Oct-Dec;30-31:58-63. doi: 10.1016/j.ghir.2016.10.001. Epub 2016 Oct 4. Growth Horm IGF Res. 2016. PMID: 27745780 Review.
Acromegaly is a rare disease associated with significant morbidity and increased mortality. Treatment of acromegaly aims at controlling growth hormone hypersecretion, improving patients' symptoms and comorbidities and normalizing mortality. ...
Acromegaly is a rare disease associated with significant morbidity and increased mortality. Treatment of acromegaly aims at controlli …
Prevalence of morphometric vertebral fractures in "difficult" patients with acromegaly with different biochemical outcomes after multimodal treatment.
Chiloiro S, Mormando M, Bianchi A, Giampietro A, Milardi D, Bima C, Grande G, Formenti AM, Mazziotti G, Pontecorvi A, Giustina A, De Marinis L. Chiloiro S, et al. Endocrine. 2018 Feb;59(2):449-453. doi: 10.1007/s12020-017-1391-5. Epub 2017 Aug 23. Endocrine. 2018. PMID: 28836162
The aim of this cross-sectional study was to evaluate the prevalence and determinants of vertebral fractures in males and females with a history of long-standing active acromegaly undergoing treatment with Pegvisomant. ...CONCLUSION: Vertebral fractures are a freque …
The aim of this cross-sectional study was to evaluate the prevalence and determinants of vertebral fractures in males and females with a
Diabetes in Cushing Disease.
Mazziotti G, Formenti AM, Frara S, Maffezzoni F, Doga M, Giustina A. Mazziotti G, et al. Curr Diab Rep. 2017 May;17(5):32. doi: 10.1007/s11892-017-0860-9. Curr Diab Rep. 2017. PMID: 28364356 Review.
Diabetes mellitus is a frequent and early complication of CD with important diagnostic, prognostic and therapeutic implications. ...Moreover, diabetes mellitus is often difficult to be controlled in CD requiring a careful and dedicated therapeutic approach. ...
Diabetes mellitus is a frequent and early complication of CD with important diagnostic, prognostic and therapeutic implications. ...M …
Biochemical evaluation of patients with active acromegaly and type 2 diabetes mellitus: efficacy and safety of the galanin test.
Mazziotti G, Bonadonna S, Doga M, Patelli I, Gazzaruso C, Solerte SB, De Menis E, Giustina A. Mazziotti G, et al. Neuroendocrinology. 2008;88(4):299-304. doi: 10.1159/000144046. Epub 2008 Jul 10. Neuroendocrinology. 2008. PMID: 18617732
In this study, we assessed GH response to galanin infusion in a series of 17 consecutive patients with active acromegaly, 7 of whom had coexistent type 2 diabetes mellitus and 10 were without either diabetes mellitus or impaired tolerance to glucose. 6 acromegalic patients …
In this study, we assessed GH response to galanin infusion in a series of 17 consecutive patients with active acromegaly, 7 of whom h …
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