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Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.
DiStefano PV, Smrcka AV, Glading AJ. DiStefano PV, et al. Among authors: glading aj. PLoS One. 2016 Sep 9;11(9):e0162338. doi: 10.1371/journal.pone.0162338. eCollection 2016. PLoS One. 2016. PMID: 27612188 Free PMC article.
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions.
Glading A, Han J, Stockton RA, Ginsberg MH. Glading A, et al. J Cell Biol. 2007 Oct 22;179(2):247-54. doi: 10.1083/jcb.200705175. J Cell Biol. 2007. PMID: 17954608 Free PMC article.
Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling.
Glading AJ, Ginsberg MH. Glading AJ, et al. Dis Model Mech. 2010 Jan-Feb;3(1-2):73-83. doi: 10.1242/dmm.003293. Epub 2009 Dec 9. Dis Model Mech. 2010. PMID: 20007487 Free PMC article.
Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo.
Corr M, Lerman I, Keubel JM, Ronacher L, Misra R, Lund F, Sarelius IH, Glading AJ. Corr M, et al. Among authors: glading aj. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2702-10. doi: 10.1161/ATVBAHA.112.300115. Epub 2012 Aug 23. Arterioscler Thromb Vasc Biol. 2012. PMID: 22922958 Free PMC article.
KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.
DiStefano PV, Kuebel JM, Sarelius IH, Glading AJ. DiStefano PV, et al. Among authors: glading aj. J Biol Chem. 2014 Nov 21;289(47):33054-65. doi: 10.1074/jbc.M114.582304. Epub 2014 Oct 15. J Biol Chem. 2014. PMID: 25320085 Free PMC article.
Control of vascular permeability by adhesion molecules.
Sarelius IH, Glading AJ. Sarelius IH, et al. Among authors: glading aj. Tissue Barriers. 2015 Apr 3;3(1-2):e985954. doi: 10.4161/21688370.2014.985954. eCollection 2015. Tissue Barriers. 2015. PMID: 25838987 Free PMC article.
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.
Goitre L, DiStefano PV, Moglia A, Nobiletti N, Baldini E, Trabalzini L, Keubel J, Trapani E, Shuvaev VV, Muzykantov VR, Sarelius IH, Retta SF, Glading AJ. Goitre L, et al. Among authors: glading aj. Sci Rep. 2017 Aug 15;7(1):8296. doi: 10.1038/s41598-017-08373-4. Sci Rep. 2017. PMID: 28811547 Free PMC article.
VEGF signalling enhances lesion burden in KRIT1 deficient mice.
DiStefano PV, Glading AJ. DiStefano PV, et al. Among authors: glading aj. J Cell Mol Med. 2020 Jan;24(1):632-639. doi: 10.1111/jcmm.14773. Epub 2019 Nov 20. J Cell Mol Med. 2020. PMID: 31746130 Free PMC article.
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.
Chou FL, Hill JM, Hsieh JC, Pouyssegur J, Brunet A, Glading A, Uberall F, Ramos JW, Werner MH, Ginsberg MH. Chou FL, et al. Among authors: glading a. J Biol Chem. 2003 Dec 26;278(52):52587-97. doi: 10.1074/jbc.M309322200. Epub 2003 Sep 23. J Biol Chem. 2003. PMID: 14506247
Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.
Krueger J, Chou FL, Glading A, Schaefer E, Ginsberg MH. Krueger J, et al. Among authors: glading a. Mol Biol Cell. 2005 Aug;16(8):3552-61. doi: 10.1091/mbc.e04-11-1007. Epub 2005 May 25. Mol Biol Cell. 2005. PMID: 15917297 Free PMC article.
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