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The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease.
Rother RP, Bell L, Hillmen P, Gladwin MT. Rother RP, et al. Among authors: gladwin mt. JAMA. 2005 Apr 6;293(13):1653-62. doi: 10.1001/jama.293.13.1653. JAMA. 2005. PMID: 15811985 Review.
Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease.
Gladwin MT, Kanias T, Kim-Shapiro DB. Gladwin MT, et al. J Clin Invest. 2012 Apr;122(4):1205-8. doi: 10.1172/JCI62972. Epub 2012 Mar 26. J Clin Invest. 2012. PMID: 22446184 Free PMC article.
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.
Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT. Donadee C, et al. Among authors: gladwin mt. Circulation. 2011 Jul 26;124(4):465-76. doi: 10.1161/CIRCULATIONAHA.110.008698. Epub 2011 Jul 11. Circulation. 2011. PMID: 21747051 Free PMC article.
Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin.
Minneci PC, Deans KJ, Zhi H, Yuen PS, Star RA, Banks SM, Schechter AN, Natanson C, Gladwin MT, Solomon SB. Minneci PC, et al. Among authors: gladwin mt. J Clin Invest. 2005 Dec;115(12):3409-17. doi: 10.1172/JCI25040. Epub 2005 Nov 17. J Clin Invest. 2005. PMID: 16294219 Free PMC article.
Erythrocytes are the major intravascular storage sites of nitrite in human blood.
Dejam A, Hunter CJ, Pelletier MM, Hsu LL, Machado RF, Shiva S, Power GG, Kelm M, Gladwin MT, Schechter AN. Dejam A, et al. Among authors: gladwin mt. Blood. 2005 Jul 15;106(2):734-9. doi: 10.1182/blood-2005-02-0567. Epub 2005 Mar 17. Blood. 2005. PMID: 15774613 Free PMC article.
Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis.
Gladwin MT, Kim-Shapiro DB. Gladwin MT, et al. Curr Opin Hematol. 2009 Nov;16(6):515-23. doi: 10.1097/MOH.0b013e32833157f4. Curr Opin Hematol. 2009. PMID: 19701085 Review.
The potential of Angeli's salt to decrease nitric oxide scavenging by plasma hemoglobin.
He X, Azarov I, Jeffers A, Presley T, Richardson J, King SB, Gladwin MT, Kim-Shapiro DB. He X, et al. Among authors: gladwin mt. Free Radic Biol Med. 2008 Apr 1;44(7):1420-32. doi: 10.1016/j.freeradbiomed.2007.12.038. Epub 2008 Jan 11. Free Radic Biol Med. 2008. PMID: 18243145 Free PMC article.
Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics.
Kim-Shapiro DB, Schechter AN, Gladwin MT. Kim-Shapiro DB, et al. Among authors: gladwin mt. Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):697-705. doi: 10.1161/01.ATV.0000204350.44226.9a. Epub 2006 Jan 19. Arterioscler Thromb Vasc Biol. 2006. PMID: 16424350 Review.
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.
Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO 3rd, Schechter AN, Gladwin MT. Reiter CD, et al. Among authors: gladwin mt. Nat Med. 2002 Dec;8(12):1383-9. doi: 10.1038/nm1202-799. Epub 2002 Nov 11. Nat Med. 2002. PMID: 12426562
Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis.
Minneci PC, Deans KJ, Shiva S, Zhi H, Banks SM, Kern S, Natanson C, Solomon SB, Gladwin MT. Minneci PC, et al. Among authors: gladwin mt. Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H743-54. doi: 10.1152/ajpheart.00151.2008. Epub 2008 Jun 13. Am J Physiol Heart Circ Physiol. 2008. PMID: 18552166 Free PMC article.
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