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M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.
Glantschnig H, Fisher JE, Wesolowski G, Rodan GA, Reszka AA. Glantschnig H, et al. Cell Death Differ. 2003 Oct;10(10):1165-77. doi: 10.1038/sj.cdd.4401285. Cell Death Differ. 2003. PMID: 14502240
Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins.
Luegmayr E, Glantschnig H, Wesolowski GA, Gentile MA, Fisher JE, Rodan GA, Reszka AA. Luegmayr E, et al. Among authors: glantschnig h. Cell Death Differ. 2004 Jul;11 Suppl 1:S108-18. doi: 10.1038/sj.cdd.4401399. Cell Death Differ. 2004. PMID: 15017384
A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling.
Kitagawa H, Ray WJ, Glantschnig H, Nantermet PV, Yu Y, Leu CT, Harada S, Kato S, Freedman LP. Kitagawa H, et al. Among authors: glantschnig h. Mol Cell Biol. 2007 Nov;27(21):7486-96. doi: 10.1128/MCB.00409-07. Epub 2007 Aug 20. Mol Cell Biol. 2007. PMID: 17709391 Free PMC article. Retracted.
Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation.
Glantschnig H, Rodan GA, Reszka AA. Glantschnig H, et al. J Biol Chem. 2002 Nov 8;277(45):42987-96. doi: 10.1074/jbc.M208538200. Epub 2002 Sep 9. J Biol Chem. 2002. PMID: 12223493
Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis.
Ma B, Luo B, Euler DH, Cusick TE, Wesolowski G, Glantschnig H, Duong LT, Ou Y, Carroll SS, Lubbers LS. Ma B, et al. Among authors: glantschnig h. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):435-441. doi: 10.1007/s00210-017-1356-5. Epub 2017 Feb 20. Naunyn Schmiedebergs Arch Pharmacol. 2017. PMID: 28220210 Clinical Trial.
Determination of in Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics.
Murphy DJ, Ou Y, Euler DH, Wessner K, Adamski S, Luo B, Wesolowski GA, Vogel R, Glantschnig H, Lubbers LS, Carroll SS, Lai MT. Murphy DJ, et al. Among authors: glantschnig h. J Am Chem Soc. 2015 Sep 9;137(35):11230-3. doi: 10.1021/jacs.5b06518. Epub 2015 Aug 27. J Am Chem Soc. 2015. PMID: 26301491
Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation.
Beaumont V, Thompson SA, Choudhry F, Nuthall H, Glantschnig H, Lipfert L, David GR, Swain CJ, McAllister G, Munoz-Sanjuan I. Beaumont V, et al. Among authors: glantschnig h. Mol Cell Neurosci. 2007 Aug;35(4):513-24. doi: 10.1016/j.mcn.2007.03.004. Epub 2007 Mar 14. Mol Cell Neurosci. 2007. PMID: 17588772
Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo.
Glantschnig H, Hampton RA, Lu P, Zhao JZ, Vitelli S, Huang L, Haytko P, Cusick T, Ireland C, Jarantow SW, Ernst R, Wei N, Nantermet P, Scott KR, Fisher JE, Talamo F, Orsatti L, Reszka AA, Sandhu P, Kimmel D, Flores O, Strohl W, An Z, Wang F. Glantschnig H, et al. J Biol Chem. 2010 Dec 17;285(51):40135-47. doi: 10.1074/jbc.M110.166892. Epub 2010 Oct 7. J Biol Chem. 2010. PMID: 20929859 Free PMC article.
Suppression of cathepsin K biomarker in synovial fluid as a free-drug-driven process.
Ma B, Wesolowski G, Luo B, Lifsted T, Wessner K, Adamson G, Glantschnig H, Lubbers LS. Ma B, et al. Among authors: glantschnig h. J Circ Biomark. 2019 Jan 7;8:1849454418821819. doi: 10.1177/1849454418821819. eCollection 2019 Jan-Dec. J Circ Biomark. 2019. PMID: 30671145 Free PMC article.
Pharmacodynamic responses to combined treatment regimens with the calcium sensing receptor antagonist JTT-305/MK-5442 and alendronate in osteopenic ovariectomized rats.
Fisher JE, Scott K, Wei N, Zhao JZ, Cusick T, Tijerina M, Karanam B, Duong L, Glantschnig H. Fisher JE, et al. Among authors: glantschnig h. Bone. 2012 Jun;50(6):1332-42. doi: 10.1016/j.bone.2012.03.004. Epub 2012 Mar 14. Bone. 2012. PMID: 22445539
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