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In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery.
Prakash C, Sharma R, Gleave M, Nedderman A. Prakash C, et al. Among authors: gleave m. Curr Drug Metab. 2008 Nov;9(9):952-64. doi: 10.2174/138920008786485209. Curr Drug Metab. 2008. PMID: 18991592
Evolution of an open-access quantitative bioanalytical mass spectrometry service in a drug discovery environment.
Wright P, Chassaing C, Cussans N, Gibson D, Green C, Gleave M, Jones R, Macrae P, Saunders K. Wright P, et al. Among authors: gleave m. Biomed Chromatogr. 2006 Jun-Jul;20(6-7):585-96. doi: 10.1002/bmc.668. Biomed Chromatogr. 2006. PMID: 16779781
Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers.
Vourvahis M, Gleave M, Nedderman AN, Hyland R, Gardner I, Howard M, Kempshall S, Collins C, LaBadie R. Vourvahis M, et al. Among authors: gleave m. Drug Metab Dispos. 2010 May;38(5):789-800. doi: 10.1124/dmd.109.031252. Epub 2010 Feb 2. Drug Metab Dispos. 2010. PMID: 20124396 Clinical Trial.
Simultaneous qualitative and quantitative metabolism data generation: a convenient marriage?
Nedderman AN, Savage ME, Gleave M, Haynes JJ. Nedderman AN, et al. Among authors: gleave m. Bioanalysis. 2012 May;4(9):1009-12. doi: 10.4155/bio.12.32. Bioanalysis. 2012. PMID: 22612682 No abstract available.
The strengths of mass spectrometry are not just sensitivity and selectivity.
Gleave M. Gleave M. Bioanalysis. 2011 Feb;3(3):245-7. doi: 10.4155/bio.10.195. Bioanalysis. 2011. PMID: 21320041 No abstract available.
A single-center, open-label study investigating the excretion balance, pharmacokinetics, metabolism, and absolute bioavailability of a single oral dose of [14C]-labeled idasanutlin and an intravenous tracer dose of [13C]-labeled idasanutlin in a single cohort of patients with solid tumors.
Pápai Z, Chen LC, Da Costa D, Blotner S, Vazvaei F, Gleave M, Jones R, Zhi J. Pápai Z, et al. Among authors: gleave m. Cancer Chemother Pharmacol. 2019 Jul;84(1):93-103. doi: 10.1007/s00280-019-03851-0. Epub 2019 May 6. Cancer Chemother Pharmacol. 2019. PMID: 31062077 Clinical Trial.
Integrated Expression of Circulating miR375 and miR371 to Identify Teratoma and Active Germ Cell Malignancy Components in Malignant Germ Cell Tumors.
Nappi L, Thi M, Adra N, Hamilton RJ, Leao R, Lavoie JM, Soleimani M, Eigl BJ, Chi K, Gleave M, So A, Black PC, Bell R, Daneshmand S, Cary C, Masterson T, Einhorn L, Nichols C, Kollmannsberger C. Nappi L, et al. Among authors: gleave m. Eur Urol. 2020 Nov 3:S0302-2838(20)30813-7. doi: 10.1016/j.eururo.2020.10.024. Online ahead of print. Eur Urol. 2020. PMID: 33158661
Improving prostate cancer classification in H&E tissue micro arrays using Ki67 and P63 histopathology.
Shao Y, Nir G, Fazli L, Goldenberg L, Gleave M, Black P, Wang J, Salcudean S. Shao Y, et al. Among authors: gleave m. Comput Biol Med. 2020 Oct 14;127:104053. doi: 10.1016/j.compbiomed.2020.104053. Online ahead of print. Comput Biol Med. 2020. PMID: 33126125
Autoantibody Landscape in Patients with Advanced Prostate Cancer.
Chen WS, Haynes WA, Waitz R, Kamath K, Vega-Crespo A, Shrestha R, Zhang M, Foye A, Baselga Carretero I, Perez Garcilazo I, Zhang M, Zhao SG, Sjöström M, Quigley DA, Chou J, Beer TM, Rettig M, Gleave M, Evans CP, Lara P, Chi KN, Reiter RE, Alumkal JJ, Ashworth A, Aggarwal R, Small EJ, Daugherty PS, Ribas A, Oh DY, Shon JC, Feng FY. Chen WS, et al. Among authors: gleave m. Clin Cancer Res. 2020 Sep 23. doi: 10.1158/1078-0432.CCR-20-1966. Online ahead of print. Clin Cancer Res. 2020. PMID: 32967941
Clusterin regulates macrophage expansion, polarization and phagocytic activity in response to inflammation in the kidneys.
Weng X, Zhao H, Guan Q, Shi G, Feng S, Gleave ME, Nguan CC, Du C. Weng X, et al. Among authors: gleave me. Immunol Cell Biol. 2020 Sep 15. doi: 10.1111/imcb.12405. Online ahead of print. Immunol Cell Biol. 2020. PMID: 32935392
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