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TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status.
Guseva NV, Rokhlin OW, Glover RA, Cohen MB. Guseva NV, et al. Among authors: glover ra. Cancer Biol Ther. 2011 Jul 1;12(1):80-5. doi: 10.4161/cbt.12.1.15721. Epub 2011 Jul 1. Cancer Biol Ther. 2011. PMID: 21525791
p53 is involved in tumor necrosis factor-alpha-induced apoptosis in the human prostatic carcinoma cell line LNCaP.
Rokhlin OW, Gudkov AV, Kwek S, Glover RA, Gewies AS, Cohen MB. Rokhlin OW, et al. Among authors: glover ra. Oncogene. 2000 Apr 6;19(15):1959-68. doi: 10.1038/sj.onc.1203453. Oncogene. 2000. PMID: 10773886
Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7.
Rokhlin OW, Glover RA, Cohen MB. Rokhlin OW, et al. Among authors: glover ra. Cancer Res. 1998 Dec 15;58(24):5870-5. Cancer Res. 1998. PMID: 9865748
Fas-mediated apoptosis in human prostatic carcinoma cell lines.
Rokhlin OW, Bishop GA, Hostager BS, Waldschmidt TJ, Sidorenko SP, Pavloff N, Kiefer MC, Umansky SR, Glover RA, Cohen MB. Rokhlin OW, et al. Among authors: glover ra. Cancer Res. 1997 May 1;57(9):1758-68. Cancer Res. 1997. PMID: 9135020
Dominant nature of the resistance to Fas- and tumor necrosis factor-alpha-mediated apoptosis in human prostatic carcinoma cell lines.
Rokhlin OW, Hostager BS, Bishop GA, Sidorenko SP, Glover RA, Gudkov AV, Cohen MB. Rokhlin OW, et al. Among authors: glover ra. Cancer Res. 1997 Sep 15;57(18):3941-3. Cancer Res. 1997. PMID: 9307276
P53 and the proteasome regulate androgen receptor activity.
Guseva NV, Rokhlin OW, Glover RA, Cohen MB. Guseva NV, et al. Among authors: glover ra. Cancer Biol Ther. 2012 May;13(7):553-8. doi: 10.4161/cbt.19605. Epub 2012 May 1. Cancer Biol Ther. 2012. PMID: 22407029
KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer.
Rokhlin OW, Guseva NV, Taghiyev AF, Glover RA, Cohen MB. Rokhlin OW, et al. Among authors: glover ra. Cancer Biol Ther. 2010 Feb;9(3):224-35. doi: 10.4161/cbt.9.3.10747. Epub 2010 Feb 25. Cancer Biol Ther. 2010. PMID: 20023417
MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer.
Rokhlin OW, Scheinker VS, Taghiyev AF, Bumcrot D, Glover RA, Cohen MB. Rokhlin OW, et al. Among authors: glover ra. Cancer Biol Ther. 2008 Aug;7(8):1288-96. doi: 10.4161/cbt.7.8.6284. Epub 2008 Aug 13. Cancer Biol Ther. 2008. PMID: 18497571
Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival.
Rokhlin OW, Taghiyev AF, Bayer KU, Bumcrot D, Koteliansk VE, Glover RA, Cohen MB. Rokhlin OW, et al. Among authors: glover ra. Cancer Biol Ther. 2007 May;6(5):732-42. doi: 10.4161/cbt.6.5.3975. Epub 2007 Feb 5. Cancer Biol Ther. 2007. PMID: 17387273
TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome.
Taghiyev AF, Guseva NV, Glover RA, Rokhlin OW, Cohen MB. Taghiyev AF, et al. Among authors: glover ra. Cancer Biol Ther. 2006 Sep;5(9):1199-205. doi: 10.4161/cbt.5.9.3168. Epub 2006 Sep 9. Cancer Biol Ther. 2006. PMID: 17110788
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