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Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals.
Wesolowska-Andersen A, Zhuo Yu G, Nylander V, Abaitua F, Thurner M, Torres JM, Mahajan A, Gloyn AL, McCarthy MI. Wesolowska-Andersen A, et al. Among authors: gloyn al. Elife. 2020 Jan 27;9:e51503. doi: 10.7554/eLife.51503. Elife. 2020. PMID: 31985400 Free PMC article.
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Dwivedi OP, Lehtovirta M, Hastoy B, Chandra V, Krentz NAJ, Kleiner S, Jain D, Richard AM, Abaitua F, Beer NL, Grotz A, Prasad RB, Hansson O, Ahlqvist E, Krus U, Artner I, Suoranta A, Gomez D, Baras A, Champon B, Payne AJ, Moralli D, Thomsen SK, Kramer P, Spiliotis I, Ramracheya R, Chabosseau P, Theodoulou A, Cheung R, van de Bunt M, Flannick J, Trombetta M, Bonora E, Wolheim CB, Sarelin L, Bonadonna RC, Rorsman P, Davies B, Brosnan J, McCarthy MI, Otonkoski T, Lagerstedt JO, Rutter GA, Gromada J, Gloyn AL, Tuomi T, Groop L. Dwivedi OP, et al. Nat Genet. 2019 Nov;51(11):1596-1606. doi: 10.1038/s41588-019-0513-9. Epub 2019 Nov 1. Nat Genet. 2019. PMID: 31676859 Free PMC article.
Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).
Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC; UK Prospective Diabetes Study (UKPDS 53). Gloyn AL, et al. Diabet Med. 2001 Mar;18(3):206-12. doi: 10.1046/j.1464-5491.2001.00449.x. Diabet Med. 2001. PMID: 11318841 Clinical Trial.
The genetics of type 2 diabetes.
Gloyn AL, McCarthy MI. Gloyn AL, et al. Best Pract Res Clin Endocrinol Metab. 2001 Sep;15(3):293-308. doi: 10.1053/beem.2001.0147. Best Pract Res Clin Endocrinol Metab. 2001. PMID: 11554772 Review.
Complete glucokinase deficiency is not a common cause of permanent neonatal diabetes.
Gloyn AL, Ellard S, Shield JP, Temple IK, Mackay DJ, Polak M, Barrett T, Hattersley AT. Gloyn AL, et al. Diabetologia. 2002 Feb;45(2):290. doi: 10.1007/s00125-001-0746-9. Diabetologia. 2002. PMID: 11942315 No abstract available.
Human calcium/calmodulin-dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with type II diabetes.
Gloyn AL, Desai M, Clark A, Levy JC, Holman RR, Frayling TM, Hattersley AT, Ashcroft SJ. Gloyn AL, et al. Diabetologia. 2002 Apr;45(4):580-3. doi: 10.1007/s00125-002-0779-8. Diabetologia. 2002. PMID: 12032636
The role of the HNF4alpha enhancer in type 2 diabetes.
Mitchell SM, Gloyn AL, Owen KR, Hattersley AT, Frayling TM. Mitchell SM, et al. Mol Genet Metab. 2002 Jun;76(2):148-51. doi: 10.1016/S1096-7192(02)00027-6. Mol Genet Metab. 2002. PMID: 12083813
A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations.
Frayling TM, Hattersley AT, McCarthy A, Holly J, Mitchell SM, Gloyn AL, Owen K, Davies D, Smith GD, Ben-Shlomo Y. Frayling TM, et al. Diabetes. 2002 Jul;51(7):2313-6. doi: 10.2337/diabetes.51.7.2313. Diabetes. 2002. PMID: 12086966
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