Gluchowski C - Search Results

1

Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists.

Rueeger H, Rigollier P, Yamaguchi Y, Schmidlin T, Schilling W, Criscione L, Whitebread S, Chiesi M, Walker MW, Dhanoa D, Islam I, Zhang J, Gluchowski C. Rueeger H, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1175-9. doi: 10.1016/s0960-894x(00)00177-3. Bioorg Med Chem Lett. 2000. PMID: 10866375

2

Discovery of potent and selective small molecule NPY Y5 receptor antagonists.

Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C. Islam I, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1767-9. doi: 10.1016/s0960-894x(02)00287-1. Bioorg Med Chem Lett. 2002. PMID: 12067557

3

High-throughput synthesis optimization of sulfonamide NPY Y5 antagonists.

Finn J, Pelham D, Walker MW, Gluchowski C. Finn J, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1771-4. doi: 10.1016/s0960-894x(02)00288-3. Bioorg Med Chem Lett. 2002. PMID: 12067558

4

Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites.

Du P, Salon JA, Tamm JA, Hou C, Cui W, Walker MW, Adham N, Dhanoa DS, Islam I, Vaysse PJ, Dowling B, Shifman Y, Boyle N, Rueger H, Schmidlin T, Yamaguchi Y, Branchek TA, Weinshank RL, Gluchowski C. Du P, et al. Among authors: gluchowski c. Protein Eng. 1997 Feb;10(2):109-17. doi: 10.1093/protein/10.2.109. Protein Eng. 1997. PMID: 9089810

5

Phenylacetamides as selective alpha-1A adrenergic receptor antagonists.

Patane MA, DiPardo RM, Newton RC, Price RP, Broten TP, Chang RS, Ransom RW, Di Salvo J, Nagarathnam D, Forray C, Gluchowski C, Bock MG. Patane MA, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1621-4. doi: 10.1016/s0960-894x(00)00307-3. Bioorg Med Chem Lett. 2000. PMID: 10937709

6

Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective alpha1a-adrenergic receptor antagonists.

Lagu B, Tian D, Chiu G, Nagarathnam D, Fang J, Shen Q, Forray C, Ransom RW, Chang RS, Vyas KP, Zhang K, Gluchowski C. Lagu B, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 2000 Jan 17;10(2):175-8. doi: 10.1016/s0960-894x(99)00653-8. Bioorg Med Chem Lett. 2000. PMID: 10673105

7

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains.

Lagu B, Tian D, Nagarathnam D, Marzabadi MR, Wong WC, Miao SW, Zhang F, Sun W, Chiu G, Fang J, Forray C, Chang RS, Ransom RW, Chen TB, O'Malley S, Zhang K, Vyas KP, Gluchowski C. Lagu B, et al. Among authors: gluchowski c. J Med Chem. 1999 Nov 18;42(23):4794-803. doi: 10.1021/jm990202+. J Med Chem. 1999. PMID: 10579842

8

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series.

Wong WC, Sun W, Lagu B, Tian D, Marzabadi MR, Zhang F, Nagarathnam D, Miao SW, Wetzel JM, Peng J, Forray C, Chang RS, Chen TB, Ransom R, O'Malley S, Broten TP, Kling P, Vyas KP, Zhang K, Gluchowski C. Wong WC, et al. Among authors: gluchowski c. J Med Chem. 1999 Nov 18;42(23):4804-13. doi: 10.1021/jm9902032. J Med Chem. 1999. PMID: 10579843

9

Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.

Konkel MJ, Wetzel JM, Cahir M, Craig DA, Noble SA, Gluchowski C. Konkel MJ, et al. Among authors: gluchowski c. J Med Chem. 2005 Apr 21;48(8):3076-9. doi: 10.1021/jm0491391. J Med Chem. 2005. PMID: 15828846

10

Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.

Nagarathnam D, Wetzel JM, Miao SW, Marzabadi MR, Chiu G, Wong WC, Hong X, Fang J, Forray C, Branchek TA, Heydorn WE, Chang RS, Broten T, Schorn TW, Gluchowski C. Nagarathnam D, et al. Among authors: gluchowski c. J Med Chem. 1998 Dec 17;41(26):5320-33. doi: 10.1021/jm980506g. J Med Chem. 1998. PMID: 9857099

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