Gluchowski C - Search Results

1

Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.

Konkel MJ, Wetzel JM, Cahir M, Craig DA, Noble SA, Gluchowski C. Konkel MJ, et al. Among authors: gluchowski c. J Med Chem. 2005 Apr 21;48(8):3076-9. doi: 10.1021/jm0491391. J Med Chem. 2005. PMID: 15828846

2

Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.

Wetzel JM, Miao SW, Forray C, Borden LA, Branchek TA, Gluchowski C. Wetzel JM, et al. Among authors: gluchowski c. J Med Chem. 1995 May 12;38(10):1579-81. doi: 10.1021/jm00010a001. J Med Chem. 1995. PMID: 7752182 No abstract available.

3

Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.

Nagarathnam D, Wetzel JM, Miao SW, Marzabadi MR, Chiu G, Wong WC, Hong X, Fang J, Forray C, Branchek TA, Heydorn WE, Chang RS, Broten T, Schorn TW, Gluchowski C. Nagarathnam D, et al. Among authors: gluchowski c. J Med Chem. 1998 Dec 17;41(26):5320-33. doi: 10.1021/jm980506g. J Med Chem. 1998. PMID: 9857099

4

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series.

Wong WC, Sun W, Lagu B, Tian D, Marzabadi MR, Zhang F, Nagarathnam D, Miao SW, Wetzel JM, Peng J, Forray C, Chang RS, Chen TB, Ransom R, O'Malley S, Broten TP, Kling P, Vyas KP, Zhang K, Gluchowski C. Wong WC, et al. Among authors: gluchowski c. J Med Chem. 1999 Nov 18;42(23):4804-13. doi: 10.1021/jm9902032. J Med Chem. 1999. PMID: 10579843

5

Modeling and mutagenesis of the human alpha 1a-adrenoceptor: orientation and function of transmembrane helix V sidechains.

Wetzel JM, Salon JA, Tamm JA, Forray C, Craig D, Nakanishi H, Cui W, Vaysse PJ, Chiu G, Weinshank RL, Hartig PR, Branchek TA, Gluchowski C. Wetzel JM, et al. Among authors: gluchowski c. Recept Channels. 1996;4(3):165-77. Recept Channels. 1996. PMID: 9014240

6

Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.

Wong WC, Chiu G, Wetzel JM, Marzabadi MR, Nagarathnam D, Wang D, Fang J, Miao SW, Hong X, Forray C, Vaysse PJ, Branchek TA, Gluchowski C, Tang R, Lepor H. Wong WC, et al. Among authors: gluchowski c. J Med Chem. 1998 Jul 2;41(14):2643-50. doi: 10.1021/jm980077m. J Med Chem. 1998. PMID: 9651170

7

Design and synthesis of novel dihydropyridine alpha-1a antagonists.

Marzabadi MR, Hong X, Nagarathnam D, Miao SW, Chiu G, Wong WC, Wetzel JM, Fang J, Forray C, Chen TB, O'Malley SS, Chang RS, Gluchowski C. Marzabadi MR, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. doi: 10.1016/s0960-894x(99)00484-9. Bioorg Med Chem Lett. 1999. PMID: 10522703

8

De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.

Lagu B, Tian D, Jeon Y, Li C, Wetzel JM, Nagarathnam D, Shen Q, Forray C, Chang RS, Broten TP, Ransom RW, Chan TB, O'Malley SS, Schorn TW, Rodrigues AD, Kassahun K, Pettibone DJ, Freidinger RO, Gluchowski C. Lagu B, et al. Among authors: gluchowski c. J Med Chem. 2000 Jul 27;43(15):2775-8. doi: 10.1021/jm000085e. J Med Chem. 2000. PMID: 10956183 No abstract available.

9

Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective alpha1a-adrenergic receptor antagonists.

Lagu B, Tian D, Chiu G, Nagarathnam D, Fang J, Shen Q, Forray C, Ransom RW, Chang RS, Vyas KP, Zhang K, Gluchowski C. Lagu B, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 2000 Jan 17;10(2):175-8. doi: 10.1016/s0960-894x(99)00653-8. Bioorg Med Chem Lett. 2000. PMID: 10673105

10

Discovery of potent and selective small molecule NPY Y5 receptor antagonists.

Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C. Islam I, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1767-9. doi: 10.1016/s0960-894x(02)00287-1. Bioorg Med Chem Lett. 2002. PMID: 12067557

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