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2004 3
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Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial-Mesenchymal Transition and Responds to Oxidative Stress.
Wang Q, Karvelsson ST, Kotronoulas A, Gudjonsson T, Halldorsson S, Rolfsson O. Wang Q, et al. Mol Cell Proteomics. 2022 Feb;21(2):100185. doi: 10.1016/j.mcpro.2021.100185. Epub 2021 Dec 17. Mol Cell Proteomics. 2022. PMID: 34923141 Free PMC article.
Comparative analysis of D492 and D492M to tumorigenic D492HER2 differentiated metabolic markers of migration from those of invasion. Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) was one of the top dysregulated enzymes in D …
Comparative analysis of D492 and D492M to tumorigenic D492HER2 differentiated metabolic markers of migration from those of invasion. Glut
Cancer-associated fibroblast expression of glutamine fructose-6-phosphate aminotransferase 2 (GFPT2) is a prognostic marker in gastric cancer.
Yang S, Li G, Yin X, Wang Y, Jiang X, Bian X, Fang T, Yin S, Zhang L, Xue Y. Yang S, et al. J Pathol Clin Res. 2023 Sep;9(5):391-408. doi: 10.1002/cjp2.333. Epub 2023 Jul 3. J Pathol Clin Res. 2023. PMID: 37395335 Free PMC article.
Glutamine fructose-6-phosphate aminotransferase 2 (GFPT2) is a rate-limiting enzyme in hexosamine biosynthesis involved in the occurrence and progress of many cancers. ...The mRNA of GFPT2 was highly expressed in the tumor (p <
Glutamine fructose-6-phosphate aminotransferase 2 (GFPT2) is a rate-limiting enzyme in hexosamine
NF-kappaB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer.
Szymura SJ, Zaemes JP, Allison DF, Clift SH, D'Innocenzi JM, Gray LG, McKenna BD, Morris BB, Bekiranov S, LeGallo RD, Jones DR, Mayo MW. Szymura SJ, et al. Cell Commun Signal. 2019 Mar 18;17(1):24. doi: 10.1186/s12964-019-0335-5. Cell Commun Signal. 2019. PMID: 30885209 Free PMC article.
Work presented here indicates that mesenchymal NSCLC upregulates glutamine-fructose-6-phosphate transaminase 2 (GFPT2). GFPT2 is the rate-limiting enzyme in the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNA …
Work presented here indicates that mesenchymal NSCLC upregulates glutamine-fructose-6-phosphate transaminase
Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) promotes the EMT of serous ovarian cancer by activating the hexosamine biosynthetic pathway to increase the nuclear location of beta-catenin.
Zhou L, Luo M, Cheng LJ, Li RN, Liu B, Linghu H. Zhou L, et al. Pathol Res Pract. 2019 Dec;215(12):152681. doi: 10.1016/j.prp.2019.152681. Epub 2019 Oct 3. Pathol Res Pract. 2019. PMID: 31685298
The hexosamine biosynthetic pathway (HBP), a branch of glucose metabolism, provides a substrate for glycosylation modification, which has a wide-ranging effect on cellular functions. Glutamine-fructose-6-phosphate transaminase 2 (GFPT2
The hexosamine biosynthetic pathway (HBP), a branch of glucose metabolism, provides a substrate for glycosylation modification, which has a …
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJ. Kim J, et al. Nat Metab. 2020 Dec;2(12):1401-1412. doi: 10.1038/s42255-020-00316-0. Epub 2020 Nov 30. Nat Metab. 2020. PMID: 33257855 Free PMC article.
KRAS/LKB1 co-mutant cells contain high levels of HBP metabolites, higher flux through the HBP pathway and elevated dependence on the HBP enzyme glutamine-fructose-6-phosphate transaminase [isomerizing] 2 (GFPT2). GFPT2 inhib …
KRAS/LKB1 co-mutant cells contain high levels of HBP metabolites, higher flux through the HBP pathway and elevated dependence on the HBP enz …
Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition.
Li J, Ye Y, Liu Z, Zhang G, Dai H, Li J, Zhou B, Li Y, Zhao Q, Huang J, Feng J, Liu S, Ruan P, Wang J, Liu J, Huang M, Liu X, Yu S, Liang Z, Ma L, Gou X, Zhang G, Chen N, Lu Y, Di C, Xia Q, Pan J, Feng R, Cai Q, Su S. Li J, et al. Nat Cancer. 2022 Apr;3(4):453-470. doi: 10.1038/s43018-022-00354-5. Epub 2022 Apr 28. Nat Cancer. 2022. PMID: 35484420
Tumor cells resistant to phagocytosis inhibit mitochondrial fission of macrophages by overexpressing glutamine-fructose-6-phosphate transaminase 2 (GFPT2), which can be targeted to improve antibody efficacy. Mechanistically, increa …
Tumor cells resistant to phagocytosis inhibit mitochondrial fission of macrophages by overexpressing glutamine-fructose-6
Enzymatic and structural properties of human glutamine:fructose-6-phosphate amidotransferase 2 (hGFAT2).
Oliveira IA, Allonso D, Fernandes TVA, Lucena DMS, Ventura GT, Dias WB, Mohana-Borges RS, Pascutti PG, Todeschini AR. Oliveira IA, et al. J Biol Chem. 2021 Jan-Jun;296:100180. doi: 10.1074/jbc.RA120.015189. Epub 2020 Dec 17. J Biol Chem. 2021. PMID: 33303629 Free PMC article.
Substrates for cellular glycosylation are synthesized in the hexosamine biosynthetic pathway, which is controlled by the glutamine:fructose-6-phosphate amidotransfera-se (GFAT). Human isoform 2 GFAT (hGFAT2) has been implicated in diabetes and c …
Substrates for cellular glycosylation are synthesized in the hexosamine biosynthetic pathway, which is controlled by the glutamine: …
Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels.
Zhang H, Jia Y, Cooper JJ, Hale T, Zhang Z, Elbein SC. Zhang H, et al. J Clin Endocrinol Metab. 2004 Feb;89(2):748-55. doi: 10.1210/jc.2003-031286. J Clin Endocrinol Metab. 2004. PMID: 14764791
Increased flux of glucose through the hexosamine biosynthetic pathway has been implicated in insulin resistance, altered insulin secretion, and diabetic nephropathy. Glutamine:fructose-6-phosphate amidotransferase (GFPT), the rate limiting enzyme in he …
Increased flux of glucose through the hexosamine biosynthetic pathway has been implicated in insulin resistance, altered insulin secretion, …
Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity.
Hu Y, Riesland L, Paterson AJ, Kudlow JE. Hu Y, et al. J Biol Chem. 2004 Jul 16;279(29):29988-93. doi: 10.1074/jbc.M401547200. Epub 2004 May 7. J Biol Chem. 2004. PMID: 15133036 Free article.
A protein encoded by a new gene with approximately 75% homology to glutamine-fructose-6-phosphate amidotransferase (GFAT) was termed GFAT2 on the basis of this similarity. ...The purified protein expressed in mammalian cells had GFAT activity. The Km v …
A protein encoded by a new gene with approximately 75% homology to glutamine-fructose-6-phosphate amidotransfera …
Roles of GFPT2 Expression Levels on the Prognosis and Tumor Microenvironment of Colon Cancer.
Ding X, Liu H, Yuan Y, Zhong Q, Zhong X. Ding X, et al. Front Oncol. 2022 Mar 7;12:811559. doi: 10.3389/fonc.2022.811559. eCollection 2022. Front Oncol. 2022. PMID: 35330716 Free PMC article.
BACKGROUND: Recently, increasing evidence has suggested that Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) is related to carcinogenesis. ...The levels of GFPT2 and drug sensitivity data were performed from CellMiner …
BACKGROUND: Recently, increasing evidence has suggested that Glutamine-fructose-6-phosphate transaminase
31 results