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1,435 results

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Page 1
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial.
Kumar P, Liu C, Hsu JW, Chacko S, Minard C, Jahoor F, Sekhar RV. Kumar P, et al. Clin Transl Med. 2021 Mar;11(3):e372. doi: 10.1002/ctm2.372. Clin Transl Med. 2021. PMID: 33783984 Free PMC article.
We previously reported that inducing deficiency of the antioxidant tripeptide glutathione (GSH) in young mice results in mitochondrial dysfunction, and that supplementing GlyNAC (combination of glycine and N-acetylcysteine [NAC]) in aged mice improves naturally-occurring G …
We previously reported that inducing deficiency of the antioxidant tripeptide glutathione (GSH) in young mice results in mitochondria …
A Redox-Activatable DNA Nanodevice for Spatially-Selective, AND-Gated Imaging of ATP and Glutathione in Mitochondria.
Chai X, Fan Z, Yu MM, Zhao J, Li L. Chai X, et al. Nano Lett. 2021 Dec 8;21(23):10047-10053. doi: 10.1021/acs.nanolett.1c03732. Epub 2021 Nov 22. Nano Lett. 2021. PMID: 34807619
Design of biosensors capable of imaging ATP and glutathione (GSH) in mitochondria remains a challenge, despite their importance in elucidating their correlated pathophysiological events. ...We demonstrate that the system allows for mitochondria-specific, corr …
Design of biosensors capable of imaging ATP and glutathione (GSH) in mitochondria remains a challenge, despite their importanc …
Mitochondrial free radical generation, oxidative stress, and aging.
Cadenas E, Davies KJ. Cadenas E, et al. Free Radic Biol Med. 2000 Aug;29(3-4):222-30. doi: 10.1016/s0891-5849(00)00317-8. Free Radic Biol Med. 2000. PMID: 11035250 Review.
Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. ...In this article we review current understandings of mitochondrial DNA, RNA, and protein …
Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial comp …
DNA-protein cross-links between abasic DNA damage and mitochondrial transcription factor A (TFAM).
Xu W, Tang J, Zhao L. Xu W, et al. Nucleic Acids Res. 2023 Jan 11;51(1):41-53. doi: 10.1093/nar/gkac1214. Nucleic Acids Res. 2023. PMID: 36583367 Free PMC article.
DNA-protein cross-links (DPCs) are deleterious DNA lesions that threaten genomic integrity. Although much has been learned about the formation and repair of DPCs in the nucleus, little is known about DPCs in mitochondria. Here, we present in vitro and in cell …
DNA-protein cross-links (DPCs) are deleterious DNA lesions that threaten genomic integrity. Although much has been learned abo …
Mitochondrial DNA and Epigenetics: Investigating Interactions with the One-Carbon Metabolism in Obesity.
Bordoni L, Petracci I, Mlodzik-Czyzewska M, Malinowska AM, Szwengiel A, Sadowski M, Gabbianelli R, Chmurzynska A. Bordoni L, et al. Oxid Med Cell Longev. 2022 Jan 29;2022:9171684. doi: 10.1155/2022/9171684. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35132354 Free PMC article.
Mitochondrial DNA copy number (mtDNAcn) has been proposed for use as a surrogate biomarker of mitochondrial health, and evidence suggests that mtDNA might be methylated. Intermediates of the one-carbon cycle (1CC), which is duplicated in the cytoplasm and mitochondria …
Mitochondrial DNA copy number (mtDNAcn) has been proposed for use as a surrogate biomarker of mitochondrial health, and evidence sugg …
Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney.
Nair AR, Lee WK, Smeets K, Swennen Q, Sanchez A, Thévenod F, Cuypers A. Nair AR, et al. Arch Toxicol. 2015 Dec;89(12):2273-89. doi: 10.1007/s00204-014-1401-9. Epub 2014 Nov 12. Arch Toxicol. 2015. PMID: 25388156
Cadmium (Cd(2+)) induces oxidative stress that ultimately defines cell fate and pathology. Mitochondria are the main energy-producing organelles in mammalian cells, but they also have a central role in formation of reactive oxygen species, cell injury, and death signaling. …
Cadmium (Cd(2+)) induces oxidative stress that ultimately defines cell fate and pathology. Mitochondria are the main energy-producing …
Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis.
Higuchi Y. Higuchi Y. J Cell Mol Med. 2004 Oct-Dec;8(4):455-64. doi: 10.1111/j.1582-4934.2004.tb00470.x. J Cell Mol Med. 2004. PMID: 15601574 Free PMC article. Review.
Chromosomal DNA and mitochondrial dysfunctions play a role on mammalian cell death induced by oxidative stress. ...Oxidative stress provides chromatin dysfunction such as single strand and double strand DNA fragmentation leading to cell death. More than 1 Mb of gian …
Chromosomal DNA and mitochondrial dysfunctions play a role on mammalian cell death induced by oxidative stress. ...Oxidative stress p …
Glutathione safeguards TET-dependent DNA demethylation and is critical for the acquisition of totipotency and pluripotency during preimplantation development.
Liu J, Chu M, Zhang J, He J, Yang Q, Tao L, Wang Z, Yao F, Zhao W, Ouyang S, Chen L, Zhang S, Gao S, Tian J, Ren L, An L. Liu J, et al. FASEB J. 2024 Feb 15;38(3):e23453. doi: 10.1096/fj.202301220R. FASEB J. 2024. PMID: 38318639
However, little is known about their relationship and developmental functions during the preimplantation window, which is essential for the acquisition of totipotency and pluripotency. Herein, we reported that glutathione (GSH), a ubiquitous intracellular protective antiox …
However, little is known about their relationship and developmental functions during the preimplantation window, which is essential for the …
High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells.
Dannenmann B, Lehle S, Hildebrand DG, Kübler A, Grondona P, Schmid V, Holzer K, Fröschl M, Essmann F, Rothfuss O, Schulze-Osthoff K. Dannenmann B, et al. Stem Cell Reports. 2015 May 12;4(5):886-98. doi: 10.1016/j.stemcr.2015.04.004. Epub 2015 Apr 30. Stem Cell Reports. 2015. PMID: 25937369 Free PMC article.
Gene profiling identified that mRNA expression of several antioxidant proteins was considerably upregulated in iPSCs. Knockdown of glutathione peroxidase-2 and depletion of glutathione impaired protection against DNA lesions. Thus, iPSCs ensure genomic integr …
Gene profiling identified that mRNA expression of several antioxidant proteins was considerably upregulated in iPSCs. Knockdown of glutat …
Mitochondrial, lysosomal and DNA damages induced by acrylamide attenuate by ellagic acid in human lymphocyte.
Salimi A, Baghal E, Ghobadi H, Hashemidanesh N, Khodaparast F, Seydi E. Salimi A, et al. PLoS One. 2021 Feb 26;16(2):e0247776. doi: 10.1371/journal.pone.0247776. eCollection 2021. PLoS One. 2021. PMID: 33635915 Free PMC article.
After 4 hours of incubation, the toxicity parameters such cytotoxicity, ROS formation, oxidized/reduced glutathione (GSH/GSSG) content, malondialdehyde (MDA) level, lysosomal membrane integrity, mitochondria membrane potential (deltapsim) collapse and 8-hydroxy-2'-d …
After 4 hours of incubation, the toxicity parameters such cytotoxicity, ROS formation, oxidized/reduced glutathione (GSH/GSSG) conten …
1,435 results