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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1915 1
1920 1
1921 1
1922 2
1925 1
1926 1
1927 2
1928 1
1929 1
1930 3
1931 2
1932 2
1935 4
1936 3
1937 5
1938 2
1939 4
1940 4
1943 2
1944 3
1945 6
1946 8
1947 19
1948 39
1949 33
1950 31
1951 38
1952 39
1953 73
1954 67
1955 97
1956 85
1957 79
1958 88
1959 85
1960 62
1961 75
1962 131
1963 224
1964 415
1965 236
1966 123
1967 140
1968 146
1969 155
1970 167
1971 174
1972 182
1973 217
1974 224
1975 513
1976 539
1977 572
1978 479
1979 454
1980 548
1981 567
1982 591
1983 717
1984 744
1985 720
1986 804
1987 835
1988 868
1989 1108
1990 1183
1991 1232
1992 1292
1993 1344
1994 1342
1995 1410
1996 1465
1997 1370
1998 1371
1999 1321
2000 1384
2001 1371
2002 1398
2003 1416
2004 1581
2005 1588
2006 1747
2007 1767
2008 1750
2009 1808
2010 1923
2011 1960
2012 2110
2013 2144
2014 2221
2015 2092
2016 2153
2017 2151
2018 2199
2019 2289
2020 2552
2021 2711
2022 2705
2023 2614
2024 903

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70,092 results

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Page 1
Serine and glycine metabolism in cancer.
Amelio I, Cutruzzolá F, Antonov A, Agostini M, Melino G. Amelio I, et al. Trends Biochem Sci. 2014 Apr;39(4):191-8. doi: 10.1016/j.tibs.2014.02.004. Epub 2014 Mar 20. Trends Biochem Sci. 2014. PMID: 24657017 Free PMC article. Review.
A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine m …
A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carb …
Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR.
Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA. Laboute T, et al. Science. 2023 Mar 31;379(6639):1352-1358. doi: 10.1126/science.add7150. Epub 2023 Mar 30. Science. 2023. PMID: 36996198 Free PMC article.
Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine is unknown. We identified an orphan G protein-coupled receptor, GPR158, as a metabotro …
Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor med …
Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.
Razak MA, Begum PS, Viswanath B, Rajagopal S. Razak MA, et al. Oxid Med Cell Longev. 2017;2017:1716701. doi: 10.1155/2017/1716701. Epub 2017 Mar 1. Oxid Med Cell Longev. 2017. PMID: 28337245 Free PMC article. Review.
Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. ...In this review we will focus on the metabolism of glycine in humans and animals and the recent findings and advances about the beneficial effects and protection of …
Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. ...In this review we will focus o …
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Borges JP, Sætra RSR, Volchuk A, Bugge M, Devant P, Sporsheim B, Kilburn BR, Evavold CL, Kagan JC, Goldenberg NM, Flo TH, Steinberg BE. Borges JP, et al. Elife. 2022 Dec 5;11:e78609. doi: 10.7554/eLife.78609. Elife. 2022. PMID: 36468682 Free PMC article.
Next, we show that glycine prevents NINJ1 clustering by either direct or indirect mechanisms. ...By positioning NINJ1 clustering as a glycine target, our data resolve a long-standing mechanism for glycine-mediated cytoprotection. ...
Next, we show that glycine prevents NINJ1 clustering by either direct or indirect mechanisms. ...By positioning NINJ1 clustering as a …
Glycine: The Smallest Anti-Inflammatory Micronutrient.
Aguayo-Cerón KA, Sánchez-Muñoz F, Gutierrez-Rojas RA, Acevedo-Villavicencio LN, Flores-Zarate AV, Huang F, Giacoman-Martinez A, Villafaña S, Romero-Nava R. Aguayo-Cerón KA, et al. Int J Mol Sci. 2023 Jul 8;24(14):11236. doi: 10.3390/ijms241411236. Int J Mol Sci. 2023. PMID: 37510995 Free PMC article. Review.
Glycine is a non-essential amino acid with many functions and effects. ...Although glycine is a non-essential amino acid, we highlight how dietary glycine supplementation is important in avoiding the development of chronic inflammation....
Glycine is a non-essential amino acid with many functions and effects. ...Although glycine is a non-essential amino acid, we h …
Glycine.
Hall JC. Hall JC. JPEN J Parenter Enteral Nutr. 1998 Nov-Dec;22(6):393-8. doi: 10.1177/0148607198022006393. JPEN J Parenter Enteral Nutr. 1998. PMID: 9829614 Review.
Glycine consists of a single carbon molecule attached to an amino and a carboxyl group. ...Glycine has just been viewed as a convenient source of nitrogen to add to solutions of nutrients. ...
Glycine consists of a single carbon molecule attached to an amino and a carboxyl group. ...Glycine has just been viewed as a c …
Glycine homeostasis requires reverse SHMT flux.
McBride MJ, Hunter CJ, Zhang Z, TeSlaa T, Xu X, Ducker GS, Rabinowitz JD. McBride MJ, et al. Cell Metab. 2024 Jan 2;36(1):103-115.e4. doi: 10.1016/j.cmet.2023.12.001. Cell Metab. 2024. PMID: 38171330
Using rodent models, here we show that the whole-body SHMT flux acts to net consume rather than produce glycine. Pharmacological inhibition of whole-body SHMT1/2 and genetic knockout of liver SHMT2 elevated circulating glycine levels up to eight-fold. ...Thus, gluco …
Using rodent models, here we show that the whole-body SHMT flux acts to net consume rather than produce glycine. Pharmacological inhi …
Glycine Transporters in Glia Cells: Structural Studies.
López-Corcuera B, Benito-Muñoz C, Aragón C. López-Corcuera B, et al. Adv Neurobiol. 2017;16:13-32. doi: 10.1007/978-3-319-55769-4_2. Adv Neurobiol. 2017. PMID: 28828604 Review.
Six transporters belonging to three solute carrier families (SLC6, SLC38, and SLC7) are capable of transporting glycine across the glial plasma membrane. The unique glial glycine-selective transporter GlyT1 (SLC6) is the main regulator of synaptic glycine con …
Six transporters belonging to three solute carrier families (SLC6, SLC38, and SLC7) are capable of transporting glycine across the gl …
Insulin resistance and glycine metabolism in humans.
Adeva-Andany M, Souto-Adeva G, Ameneiros-Rodríguez E, Fernández-Fernández C, Donapetry-García C, Domínguez-Montero A. Adeva-Andany M, et al. Amino Acids. 2018 Jan;50(1):11-27. doi: 10.1007/s00726-017-2508-0. Epub 2017 Nov 1. Amino Acids. 2018. PMID: 29094215 Review.
Plasma glycine level is low in patients with obesity or diabetes and the improvement of insulin resistance increases plasma glycine concentration. ...Glycine conjugates bile acids and other acyl moieties producing acyl-glycine derivatives. ...
Plasma glycine level is low in patients with obesity or diabetes and the improvement of insulin resistance increases plasma glycin …
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.
Rom O, Liu Y, Finney AC, Ghrayeb A, Zhao Y, Shukha Y, Wang L, Rajanayake KK, Das S, Rashdan NA, Weissman N, Delgadillo L, Wen B, Garcia-Barrio MT, Aviram M, Kevil CG, Yurdagul A Jr, Pattillo CB, Zhang J, Sun D, Hayek T, Gottlieb E, Mor I, Chen YE. Rom O, et al. Redox Biol. 2022 Jun;52:102313. doi: 10.1016/j.redox.2022.102313. Epub 2022 Apr 13. Redox Biol. 2022. PMID: 35447412 Free PMC article.
Here, following the identification of reduced circulating glycine in patients with significant coronary artery disease (sCAD), we investigated a causative role of glycine in atherosclerosis by modulating glycine availability in atheroprone mice. ...Glycine …
Here, following the identification of reduced circulating glycine in patients with significant coronary artery disease (sCAD), we inv …
70,092 results
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