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The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19.
Silvagno F, Vernone A, Pescarmona GP. Silvagno F, et al. Antioxidants (Basel). 2020 Jul 16;9(7):624. doi: 10.3390/antiox9070624. Antioxidants (Basel). 2020. PMID: 32708578 Free PMC article. Review.
The novel COVID-19 pandemic is affecting the world's population differently: mostly in the presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal cytokine storm and patients die from acute respiratory distress syndrome, whereas in many …
The novel COVID-19 pandemic is affecting the world's population differently: mostly in the presence of conditions such as aging, diab …
Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats.
Ruiz-Ramírez A, Ortiz-Balderas E, Cardozo-Saldaña G, Diaz-Diaz E, El-Hafidi M. Ruiz-Ramírez A, et al. Clin Sci (Lond). 2014 Jan 1;126(1):19-29. doi: 10.1042/CS20130164. Clin Sci (Lond). 2014. PMID: 23742196
The present study was undertaken to investigate the mechanism by which glycine, supplemented to the diet of SF (sucrose-fed) rats, modulates glutathione biosynthesis and protects against oxidative stress and altered endothelium-dependent relaxation in isolate …
The present study was undertaken to investigate the mechanism by which glycine, supplemented to the diet of SF (sucrose-fed) rats, mo …
7,8,4'-Trihydroxyisoflavone, a Metabolized Product of Daidzein, Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells.
Ko YH, Kim SK, Kwon SH, Seo JY, Lee BR, Kim YJ, Hur KH, Kim SY, Lee SY, Jang CG. Ko YH, et al. Biomol Ther (Seoul). 2019 Jul 1;27(4):363-372. doi: 10.4062/biomolther.2018.211. Biomol Ther (Seoul). 2019. PMID: 30866601 Free PMC article.
Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, the protective effects of 7,8,4'-trihydroxyisoflavone (THIF), a major metabolite of daidzein, on 6-hydroxydopamine (OHDA)-induced neur …
Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, t …
Glycine increases glyoxalase-1 function by promoting nuclear factor erythroid 2-related factor 2 translocation into the nucleus of kidney cells of streptozotocin-induced diabetic rats.
Wang Z, Zhao D, Chen L, Li J, Yuan G, Yang G, Zhang H, Guo X, Zhang J. Wang Z, et al. J Diabetes Investig. 2019 Sep;10(5):1189-1198. doi: 10.1111/jdi.13032. Epub 2019 Mar 28. J Diabetes Investig. 2019. PMID: 30825261 Free PMC article.
RESULTS: The mRNA and protein expressions, as well as the activity of Glo1, were decreased in the kidneys of diabetic rats, accompanied by diminished glutathione levels. After glycine treatment, these parameters of Glo1 function were markedly increased. ...In additi …
RESULTS: The mRNA and protein expressions, as well as the activity of Glo1, were decreased in the kidneys of diabetic rats, accompanied by d …
Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice.
Heidari R, Ghanbarinejad V, Mohammadi H, Ahmadi A, Ommati MM, Abdoli N, Aghaei F, Esfandiari A, Azarpira N, Niknahad H. Heidari R, et al. Biomed Pharmacother. 2018 Jan;97:1086-1095. doi: 10.1016/j.biopha.2017.10.166. Epub 2017 Nov 10. Biomed Pharmacother. 2018. PMID: 29136945
Moreover, glycine treatment improved mitochondrial membrane potential and restored liver mitochondrial ATP. On the other hand, it was found that glycine supplementation attenuated oxidative stress markers in the liver of BDL animals. ...
Moreover, glycine treatment improved mitochondrial membrane potential and restored liver mitochondrial ATP. On the other hand, …
Metabolomic mechanisms of gypenoside against liver fibrosis in rats: An integrative analysis of proteomics and metabolomics data.
Song YN, Dong S, Wei B, Liu P, Zhang YY, Su SB. Song YN, et al. PLoS One. 2017 Mar 14;12(3):e0173598. doi: 10.1371/journal.pone.0173598. eCollection 2017. PLoS One. 2017. PMID: 28291813 Free PMC article.
According to integrative analysis, some important pathways were found, including glycolysis or gluconeogenesis, fructose and mannose metabolism, glycine, serine and threonine metabolism, lysine degradation, arginine and proline metabolism, glutathione metabolism, an …
According to integrative analysis, some important pathways were found, including glycolysis or gluconeogenesis, fructose and mannose metabol …
Differential cytoprotection by glycine against oxidant damage to proximal tubule cells.
Sogabe K, Roeser NF, Venkatachalam MA, Weinberg JM. Sogabe K, et al. Kidney Int. 1996 Sep;50(3):845-54. doi: 10.1038/ki.1996.384. Kidney Int. 1996. PMID: 8872959 Free article.
This toxicity was blocked by DPPD or chelating the Fe, but not by glycine. All of the lesions were characterized by severe depletion of glutathione and other soluble thiols. ...Superimposition of hypoxia during tBHP exposure reduced TBARS accumulation and restore
This toxicity was blocked by DPPD or chelating the Fe, but not by glycine. All of the lesions were characterized by severe depletion …
Salicylic acid-mediated alleviation of fluoride toxicity in rice by restricting fluoride bioaccumulation and strengthening the osmolyte, antioxidant and glyoxalase systems.
Singh A, Roychoudhury A. Singh A, et al. Environ Sci Pollut Res Int. 2021 Jun 1. doi: 10.1007/s11356-021-14624-9. Online ahead of print. Environ Sci Pollut Res Int. 2021. PMID: 34075496
Exogenous application of SA (0.5 mM) enhanced the endogenous level of SA that restored the chlorophyll content and catalase activity and further escalated the activity of other enzymatic antioxidants (superoxide dismutase, guaiacol peroxidase, ascorbate peroxidase, glut
Exogenous application of SA (0.5 mM) enhanced the endogenous level of SA that restored the chlorophyll content and catalase activity …
Proton pump inhibitors versus Cryptococcus species: effects on in vitro susceptibility and melanin production.
Brilhante RS, da Rocha MG, de Oliveira JS, España JD, Pereira VS, Scm Castelo-Branco D, A Pereira-Neto W, Sidrim JJ, A Cordeiro R, Rocha MF. Brilhante RS, et al. Future Microbiol. 2019 Apr;14:489-497. doi: 10.2217/fmb-2018-0340. Epub 2019 Apr 29. Future Microbiol. 2019. PMID: 31033338
Materials & methods: Minimum inhibitory concentrations (MICs) of omeprazole, esomeprazole, rabeprazole, pantoprazole and lansoprazole against Cryptococcus spp. were determined and the effect of PPIs on melanin production was evaluated, in the presence or absence of copper sul …
Materials & methods: Minimum inhibitory concentrations (MICs) of omeprazole, esomeprazole, rabeprazole, pantoprazole and lansoprazole ag …
Metabolomics study on the intervention effect of Radix Salviae Miltiorrhizae extract in exercise-induced exhaustion rat using gas chromatography coupled to mass spectrometry.
Wang Y, Zhou W, Lyu C, Li Q, Kou F, Jiang M, Wei H. Wang Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jul 15;1178:122805. doi: 10.1016/j.jchromb.2021.122805. Epub 2021 May 27. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 34224965
The changed metabolic pathways of the potential biomarkers in response to the effect of RSM treatment for exhaustive exercise rats included in glucose metabolism (glucose, lactic acid, alanine), glutathione metabolism (glycine, glutamate, 5-oxo-proline), TCA cycle ( …
The changed metabolic pathways of the potential biomarkers in response to the effect of RSM treatment for exhaustive exercise rats included …
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