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Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats.
Ruiz-Ramírez A, Ortiz-Balderas E, Cardozo-Saldaña G, Diaz-Diaz E, El-Hafidi M. Ruiz-Ramírez A, et al. Clin Sci (Lond). 2014 Jan 1;126(1):19-29. doi: 10.1042/CS20130164. Clin Sci (Lond). 2014. PMID: 23742196
The present study was undertaken to investigate the mechanism by which glycine, supplemented to the diet of SF (sucrose-fed) rats, modulates glutathione biosynthesis and protects against oxidative stress and altered endothelium-dependent relaxat …
The present study was undertaken to investigate the mechanism by which glycine, supplemented to the diet of SF (sucrose-fed) rats, mo …
Metabolomics study on the intervention effect of Radix Salviae Miltiorrhizae extract in exercise-induced exhaustion rat using gas chromatography coupled to mass spectrometry.
Wang Y, Zhou W, Lyu C, Li Q, Kou F, Jiang M, Wei H. Wang Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jul 15;1178:122805. doi: 10.1016/j.jchromb.2021.122805. Epub 2021 May 27. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 34224965
The changed metabolic pathways of the potential biomarkers in response to the effect of RSM treatment for exhaustive exercise rats included in glucose metabolism (glucose, lactic acid, alanine), glutathione metabolism (glycine, glutamate, 5-oxo-proline), TCA cycle ( …
The changed metabolic pathways of the potential biomarkers in response to the effect of RSM treatment for exhaustive exercise rats included …
Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein.
Hidaka I, Hino K, Korenaga M, Gondo T, Nishina S, Ando M, Okuda M, Sakaida I. Hidaka I, et al. Liver Int. 2007 Aug;27(6):845-53. doi: 10.1111/j.1478-3231.2007.01492.x. Liver Int. 2007. PMID: 17617128
The aim of this study was to investigate if SNMC had an anti-oxidative effect, as oxidative stress has been proposed to be one of the mechanisms of liver injury in hepatitis C virus (HCV)-associated chronic liver diseases. ...CONCLUSIONS: Transgenic mice expr …
The aim of this study was to investigate if SNMC had an anti-oxidative effect, as oxidative stress has been proposed to …
Salicylic acid-mediated alleviation of fluoride toxicity in rice by restricting fluoride bioaccumulation and strengthening the osmolyte, antioxidant and glyoxalase systems.
Singh A, Roychoudhury A. Singh A, et al. Environ Sci Pollut Res Int. 2021 Jun 1. doi: 10.1007/s11356-021-14624-9. Online ahead of print. Environ Sci Pollut Res Int. 2021. PMID: 34075496
Exogenous application of SA (0.5 mM) enhanced the endogenous level of SA that restored the chlorophyll content and catalase activity and further escalated the activity of other enzymatic antioxidants (superoxide dismutase, guaiacol peroxidase, ascorbate peroxidase, glut
Exogenous application of SA (0.5 mM) enhanced the endogenous level of SA that restored the chlorophyll content and catalase activity …
Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice.
Heidari R, Ghanbarinejad V, Mohammadi H, Ahmadi A, Ommati MM, Abdoli N, Aghaei F, Esfandiari A, Azarpira N, Niknahad H. Heidari R, et al. Biomed Pharmacother. 2018 Jan;97:1086-1095. doi: 10.1016/j.biopha.2017.10.166. Epub 2017 Nov 10. Biomed Pharmacother. 2018. PMID: 29136945
Moreover, glycine treatment improved mitochondrial membrane potential and restored liver mitochondrial ATP. On the other hand, it was found that glycine supplementation attenuated oxidative stress markers in the liver of BDL animals. ...
Moreover, glycine treatment improved mitochondrial membrane potential and restored liver mitochondrial ATP. On the other hand, …
Glycine increases glyoxalase-1 function by promoting nuclear factor erythroid 2-related factor 2 translocation into the nucleus of kidney cells of streptozotocin-induced diabetic rats.
Wang Z, Zhao D, Chen L, Li J, Yuan G, Yang G, Zhang H, Guo X, Zhang J. Wang Z, et al. J Diabetes Investig. 2019 Sep;10(5):1189-1198. doi: 10.1111/jdi.13032. Epub 2019 Mar 28. J Diabetes Investig. 2019. PMID: 30825261 Free PMC article.
AIMS/INTRODUCTION: We have previously reported that glycine suppresses the advanced glycation end-products signaling pathway and mitigates subsequent oxidative stress in the kidneys of diabetic rats. ...In addition, the anti-oxidant capacity and the expressio …
AIMS/INTRODUCTION: We have previously reported that glycine suppresses the advanced glycation end-products signaling pathway and miti …
Differential cytoprotection by glycine against oxidant damage to proximal tubule cells.
Sogabe K, Roeser NF, Venkatachalam MA, Weinberg JM. Sogabe K, et al. Kidney Int. 1996 Sep;50(3):845-54. doi: 10.1038/ki.1996.384. Kidney Int. 1996. PMID: 8872959 Free article.
This toxicity was blocked by DPPD or chelating the Fe, but not by glycine. All of the lesions were characterized by severe depletion of glutathione and other soluble thiols. ...Extensive oxidative crosslinking of proteins is compatible with maintenance of …
This toxicity was blocked by DPPD or chelating the Fe, but not by glycine. All of the lesions were characterized by severe depletion …
Bioactive properties: enhancement of hepatoprotective, antioxidant and DNA damage protective effects of golden grey mullet protein hydrolysates against paracetamol toxicity.
Bkhairia I, Dhibi S, Nasri R, Elfeki A, Hfaiyedh N, Ben Amara I, Nasri M. Bkhairia I, et al. RSC Adv. 2018 Jun 26;8(41):23230-23240. doi: 10.1039/c8ra02178c. eCollection 2018 Jun 21. RSC Adv. 2018. PMID: 35540151 Free PMC article.
Paracetamol overdose induced marked liver damage in rats was noted by a significant increase in the activities of serum aspartate amino transferase (AST) and alanine amino transferase (ALT), and oxidative stress which was evident from decreased activity of the enzym …
Paracetamol overdose induced marked liver damage in rats was noted by a significant increase in the activities of serum aspartate amino tran …
Alterations of bronchial epithelial metabolome by cigarette smoke are reversible by an antioxidant, O-methyl-L-tyrosinyl-γ-L-glutamyl-L-cysteinylglycine.
Aug A, Altraja A, Altraja S, Laaniste L, Mahlapuu R, Soomets U, Kilk K. Aug A, et al. Am J Respir Cell Mol Biol. 2014 Oct;51(4):586-94. doi: 10.1165/rcmb.2013-0377OC. Am J Respir Cell Mol Biol. 2014. PMID: 24810251
Human bronchial epithelial cells (HBECs) have first-line contact with harmful substances during smoking, and changes in their metabolism most likely represent a defining factor in coping with the stress and development of airway diseases. This study was designed to determi …
Human bronchial epithelial cells (HBECs) have first-line contact with harmful substances during smoking, and changes in their metabolism mos …
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Tussy P, Fernández-Ramos D, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Mercado-Gómez M, Morán L, Bizkarguenaga M, Lopitz-Otsoa F, Petrov P, Bravo M, Van Liempd SM, Falcon-Perez JM, Zabala-Letona A, Carracedo A, Castell JV, Jover R, Martínez-Cruz LA, Delgado TC, Cubero FJ, Lucena MI, Andrade RJ, Mabe J, Simón J, Martínez-Chantar ML. Rodríguez-Agudo R, et al. Antioxidants (Basel). 2022 Apr 30;11(5):897. doi: 10.3390/antiox11050897. Antioxidants (Basel). 2022. PMID: 35624761 Free PMC article.
Ammonia homeostasis is altered during liver diseases and, during DILI, it is accompanied by decreased glycine N-methyltransferase (GNMT) expression and S-adenosylmethionine (AdoMet) levels that suggest a reduced methionine cycle. ...In our study, we demonstrate a GN …
Ammonia homeostasis is altered during liver diseases and, during DILI, it is accompanied by decreased glycine N-methyltransferase (GN …
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