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The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.
Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM. Gmachl M, et al. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8973-8. doi: 10.1073/pnas.97.16.8973. Proc Natl Acad Sci U S A. 2000. PMID: 10922056 Free PMC article.
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P. Wendt KS, et al. Among authors: gmachl m. Nat Struct Biol. 2001 Sep;8(9):784-8. doi: 10.1038/nsb0901-784. Nat Struct Biol. 2001. PMID: 11524682
Drugging an undruggable pocket on KRAS.
Kessler D, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Gollner A, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB. Kessler D, et al. Among authors: gmachl m. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15823-15829. doi: 10.1073/pnas.1904529116. Epub 2019 Jul 22. Proc Natl Acad Sci U S A. 2019. PMID: 31332011 Free PMC article.
Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm.
Gmachl M, Kreil G. Gmachl M, et al. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3569-73. doi: 10.1073/pnas.90.8.3569. Proc Natl Acad Sci U S A. 1993. PMID: 7682712 Free PMC article.
Anterograde flow of cargo across the golgi stack potentially mediated via bidirectional "percolating" COPI vesicles.
Orci L, Ravazzola M, Volchuk A, Engel T, Gmachl M, Amherdt M, Perrelet A, Sollner TH, Rothman JE. Orci L, et al. Among authors: gmachl m. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10400-5. doi: 10.1073/pnas.190292497. Proc Natl Acad Sci U S A. 2000. PMID: 10962035 Free PMC article.
The human sperm protein PH-20 has hyaluronidase activity.
Gmachl M, Sagan S, Ketter S, Kreil G. Gmachl M, et al. FEBS Lett. 1993 Dec 28;336(3):545-8. doi: 10.1016/0014-5793(93)80873-s. FEBS Lett. 1993. PMID: 8282124
High-level expression in Escherichia coli and rapid purification of enzymatically active honey bee venom phospholipase A2.
Dudler T, Chen WQ, Wang S, Schneider T, Annand RR, Dempcy RO, Crameri R, Gmachl M, Suter M, Gelb MH. Dudler T, et al. Biochim Biophys Acta. 1992 Dec 2;1165(2):201-10. doi: 10.1016/0005-2760(92)90188-2. Biochim Biophys Acta. 1992. PMID: 1450215
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