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Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.
Seregin SS, Rastall DP, Evnouchidou I, Aylsworth CF, Quiroga D, Kamal RP, Godbehere-Roosa S, Blum CF, York IA, Stratikos E, Amalfitano A. Seregin SS, et al. Among authors: godbehere roosa s. Autoimmunity. 2013 Dec;46(8):497-508. doi: 10.3109/08916934.2013.819855. Epub 2013 Sep 13. Autoimmunity. 2013. PMID: 24028501 Free PMC article.
Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.
Rastall DPW, Alyaquob FS, O'Connell P, Pepelyayeva Y, Peters D, Godbehere-Roosa S, Pereira-Hicks C, Aldhamen YA, Amalfitano A. Rastall DPW, et al. Among authors: godbehere roosa s. Int Immunol. 2017 Jun 1;29(6):277-289. doi: 10.1093/intimm/dxx035. Int Immunol. 2017. PMID: 28814066 Free PMC article.