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Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
Goel A, Aggarwal BB. Goel A, et al. Nutr Cancer. 2010;62(7):919-30. doi: 10.1080/01635581.2010.509835. Nutr Cancer. 2010. PMID: 20924967 Review.
Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and curry powder in the West), has been consumed by people for centuries as a dietary component and for a variety of proinflammato …
Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and …
Somatic evolution of cancer cells.
Boland CR, Goel A. Boland CR, et al. Among authors: goel a. Semin Cancer Biol. 2005 Dec;15(6):436-50. doi: 10.1016/j.semcancer.2005.06.001. Semin Cancer Biol. 2005. PMID: 16055343 Review.
Cancers develop through a process called genomic instability, which generates diversity, from which clonal evolution may occur. ...Each of these processes is associated with a unique mutational or epigenetic "signature" identifiable in the tumor cells, and there are …
Cancers develop through a process called genomic instability, which generates diversity, from which clonal evolution may occur. ...Ea …
Chemoprevention goes gourmet: different flavors of NO-aspirin.
Goel A, Gasche C, Boland CR. Goel A, et al. Mol Interv. 2005 Aug;5(4):207-10. doi: 10.1124/mi.5.4.3. Mol Interv. 2005. PMID: 16123534 No abstract available.
Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis.
Arnold CN, Goel A, Blum HE, Boland CR. Arnold CN, et al. Among authors: goel a. Cancer. 2005 Nov 15;104(10):2035-47. doi: 10.1002/cncr.21462. Cancer. 2005. PMID: 16206296
Most colorectal cancers are sporadic, but a significant proportion (5-6%) has a clear genetic background. It is now widely accepted that colorectal carcinogenesis is a multistep process involving the inactivation of a variety of tumor-suppressor and DN …
Most colorectal cancers are sporadic, but a significant proportion (5-6%) has a clear genetic background. It is now widely acc …
Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells.
Goel A, Fuerst F, Hotchkiss E, Boland CR. Goel A, et al. Cancer Biol Ther. 2006 May;5(5):529-35. doi: 10.4161/cbt.5.5.2654. Epub 2006 May 5. Cancer Biol Ther. 2006. PMID: 16627976

Similarly, both HCT116 and RKO demonstrated a significant increase in apoptosis (100-170%; p < 0.01) with 50-100 microM selenomethionine. Cell cycle arrest and apoptosis observed in HCT116 and RKO cell lines were accompanied by a marked increase in p53 protein ex

Similarly, both HCT116 and RKO demonstrated a significant increase in apoptosis (100-170%; p < 0.01) with 50-100 microM selenometh

Oncogenic T-antigen of JC virus is present frequently in human gastric cancers.
Shin SK, Li MS, Fuerst F, Hotchkiss E, Meyer R, Kim IT, Goel A, Boland CR. Shin SK, et al. Among authors: goel a. Cancer. 2006 Aug 1;107(3):481-8. doi: 10.1002/cncr.22028. Cancer. 2006. PMID: 16795066
The oncogenic potential of JCV is mediated by a transforming protein, the T-antigen (T-Ag), which is a multifunctional protein that transforms cells through interactions with various growth-regulatory genes, including p53 and pRb, and by stabilizing beta-catenin. .. …
The oncogenic potential of JCV is mediated by a transforming protein, the T-antigen (T-Ag), which is a multifunctional protein …
High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers.
Nishida N, Nagasaka T, Kashiwagi K, Boland CR, Goel A. Nishida N, et al. Among authors: goel a. Cancer Biol Ther. 2007 Apr;6(4):525-33. doi: 10.4161/cbt.6.4.3817. Cancer Biol Ther. 2007. PMID: 17457043
Therefore, a more comprehensive analysis of the genes involved in each cell cycle checkpoint regulatory pathway might be required to evaluate a possible role for involvement in CIN. ...In the cell lines with CIN, we found amplification of the Aurora-A, cyclin …
Therefore, a more comprehensive analysis of the genes involved in each cell cycle checkpoint regulatory pathway might be required to …
Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis.
Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR. Nishida N, et al. Among authors: goel a. Cancer Res. 2007 May 15;67(10):4586-94. doi: 10.1158/0008-5472.CAN-06-3464. Cancer Res. 2007. PMID: 17510384
Fractional allelic loss (FAL) was determined using 400 microsatellite markers in 81 HCCs and 77 corresponding noncancerous livers as a measure of CIN. ...
Fractional allelic loss (FAL) was determined using 400 microsatellite markers in 81 HCCs and 77 corresponding noncancerous livers as a
Curcumin as "Curecumin": from kitchen to clinic.
Goel A, Kunnumakkara AB, Aggarwal BB. Goel A, et al. Biochem Pharmacol. 2008 Feb 15;75(4):787-809. doi: 10.1016/j.bcp.2007.08.016. Epub 2007 Aug 19. Biochem Pharmacol. 2008. PMID: 17900536 Review.
Various preclinical cell culture and animal studies suggest that curcumin has potential as an antiproliferative, anti-invasive, and antiangiogenic agent; as a mediator of chemoresistance and radioresistance; as a chemopreventive agent; and as a therapeutic ag …
Various preclinical cell culture and animal studies suggest that curcumin has potential as an antiproliferative, anti-invasive, and antiangi …
JC virus T-antigen expression in sporadic adenomatous polyps of the colon.
Jung WT, Li MS, Goel A, Boland CR. Jung WT, et al. Among authors: goel a. Cancer. 2008 Mar 1;112(5):1028-36. doi: 10.1002/cncr.23266. Cancer. 2008. PMID: 18205186 Free PMC article.
Immunohistochemical staining was performed to localize T-Ag expression in the adenomas using a monoclonal antibody. For microsatellite instability analysis, 5 mononucleotide repeat markers (BAT-25, BAT-26, NR-21, NR-24, and NR-27) were coamplified in a pentaplex PCR …
Immunohistochemical staining was performed to localize T-Ag expression in the adenomas using a monoclonal antibody. For microsatellit …
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