Goffart S - Search Results

1

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.

Hangas A, Aasumets K, Kekäläinen NJ, Paloheinä M, Pohjoismäki JL, Gerhold JM, Goffart S. Hangas A, et al. Among authors: goffart s. Nucleic Acids Res. 2018 Oct 12;46(18):9625-9636. doi: 10.1093/nar/gky793. Nucleic Acids Res. 2018. PMID: 30169847 Free PMC article.

2

Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells.

Maniura-Weber K, Goffart S, Garstka HL, Montoya J, Wiesner RJ. Maniura-Weber K, et al. Among authors: goffart s. Nucleic Acids Res. 2004 Nov 16;32(20):6015-27. doi: 10.1093/nar/gkh921. Print 2004. Nucleic Acids Res. 2004. PMID: 15547250 Free PMC article.

3

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.

Pohjoismäki JL, Wanrooij S, Hyvärinen AK, Goffart S, Holt IJ, Spelbrink JN, Jacobs HT. Pohjoismäki JL, et al. Among authors: goffart s. Nucleic Acids Res. 2006;34(20):5815-28. doi: 10.1093/nar/gkl703. Epub 2006 Oct 24. Nucleic Acids Res. 2006. PMID: 17062618 Free PMC article.

4

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes.

Wanrooij S, Goffart S, Pohjoismäki JL, Yasukawa T, Spelbrink JN. Wanrooij S, et al. Among authors: goffart s. Nucleic Acids Res. 2007;35(10):3238-51. doi: 10.1093/nar/gkm215. Epub 2007 Apr 22. Nucleic Acids Res. 2007. PMID: 17452351 Free PMC article.

5

Inducible expression in human cells, purification, and in vitro assays for the mitochondrial DNA helicase Twinkle.

Goffart S, Spelbrink H. Goffart S, et al. Methods Mol Biol. 2009;554:103-19. doi: 10.1007/978-1-59745-521-3_7. Methods Mol Biol. 2009. PMID: 19513670

6

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks.

Pohjoismäki JL, Goffart S, Tyynismaa H, Willcox S, Ide T, Kang D, Suomalainen A, Karhunen PJ, Griffith JD, Holt IJ, Jacobs HT. Pohjoismäki JL, et al. Among authors: goffart s. J Biol Chem. 2009 Aug 7;284(32):21446-57. doi: 10.1074/jbc.M109.016600. Epub 2009 Jun 12. J Biol Chem. 2009. PMID: 19525233 Free PMC article.

7

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO. Dalla Rosa I, et al. Among authors: goffart s. Nucleic Acids Res. 2009 Oct;37(19):6414-28. doi: 10.1093/nar/gkp708. Epub 2009 Aug 31. Nucleic Acids Res. 2009. PMID: 19720733 Free PMC article.

8

Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.

Pohjoismäki JL, Holmes JB, Wood SR, Yang MY, Yasukawa T, Reyes A, Bailey LJ, Cluett TJ, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, Jacobs HT, Holt IJ. Pohjoismäki JL, et al. Among authors: goffart s. J Mol Biol. 2010 Apr 16;397(5):1144-55. doi: 10.1016/j.jmb.2010.02.029. Epub 2010 Feb 23. J Mol Biol. 2010. PMID: 20184890 Free PMC article.

9

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.

Pohjoismäki JL, Goffart S, Taylor RW, Turnbull DM, Suomalainen A, Jacobs HT, Karhunen PJ. Pohjoismäki JL, et al. Among authors: goffart s. PLoS One. 2010 May 3;5(5):e10426. doi: 10.1371/journal.pone.0010426. PLoS One. 2010. PMID: 20454654 Free PMC article.

10

Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA.

Pohjoismäki JL, Goffart S. Pohjoismäki JL, et al. Among authors: goffart s. Bioessays. 2011 Apr;33(4):290-9. doi: 10.1002/bies.201000137. Epub 2011 Feb 2. Bioessays. 2011. PMID: 21290399 Review.

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