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Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
Cruz MC, Goldstein AL, Blankenship J, Del Poeta M, Perfect JR, McCusker JH, Bennani YL, Cardenas ME, Heitman J. Cruz MC, et al. Among authors: goldstein al. Antimicrob Agents Chemother. 2001 Nov;45(11):3162-70. doi: 10.1128/AAC.45.11.3162-3170.2001. Antimicrob Agents Chemother. 2001. PMID: 11600372 Free PMC article.
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