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Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species.
Kalo E, Kogan-Sakin I, Solomon H, Bar-Nathan E, Shay M, Shetzer Y, Dekel E, Goldfinger N, Buganim Y, Stambolsky P, Goldstein I, Madar S, Rotter V. Kalo E, et al. Among authors: goldstein i. J Cell Sci. 2012 Nov 15;125(Pt 22):5578-86. doi: 10.1242/jcs.106815. Epub 2012 Aug 16. J Cell Sci. 2012. PMID: 22899716
p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways.
Buganim Y, Solomon H, Rais Y, Kistner D, Nachmany I, Brait M, Madar S, Goldstein I, Kalo E, Adam N, Gordin M, Rivlin N, Kogan I, Brosh R, Sefadia-Elad G, Goldfinger N, Sidransky D, Kloog Y, Rotter V. Buganim Y, et al. Among authors: goldstein i. Cancer Res. 2010 Mar 15;70(6):2274-84. doi: 10.1158/0008-5472.CAN-09-2661. Epub 2010 Mar 2. Cancer Res. 2010. PMID: 20197462
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