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N-3 fatty acid supplementation to routine statin treatment inhibits platelet function, decreases patients' daytime blood pressure, and improves inflammatory status.
Doenyas-Barak K, Berman S, Abu-Hamad R, Golik A, Rahimi-Levene N, Efrati S. Doenyas-Barak K, et al. Among authors: golik a. Eur J Clin Pharmacol. 2012 Aug;68(8):1139-46. doi: 10.1007/s00228-012-1235-4. Epub 2012 Feb 25. Eur J Clin Pharmacol. 2012. PMID: 22367427 Clinical Trial.
We examined the operating mechanisms underlying such a combination. METHODS: Thirty-two hypercholesterolemic patients aged 30-70 years with hypercholesterolemia controlled by statins, received sequential treatments with placebo followed by 1.9 g/day of N-3 fatty acids for …
We examined the operating mechanisms underlying such a combination. METHODS: Thirty-two hypercholesterolemic patients aged 30-70 year …
The effect of levothyroxine on arterial stiffness and lipid profile in patients with subclinical hypothyroidism.
Peleg RK, Efrati S, Benbassat C, Fygenzo M, Golik A. Peleg RK, et al. Among authors: golik a. Thyroid. 2008 Aug;18(8):825-30. doi: 10.1089/thy.2007.0359. Thyroid. 2008. PMID: 18651824

This increase, calculated as the AIx, is a good expression of central aortic pressure. RESULTS: After accomplishing euthyroidism, the AIx decreased from 17.2 +/- 8.3 to 14.3 +/- 6.5 (p < 0.01) and AIx percentage decreased from 36.2 +/- 11.5 to 33.2 +/- 9.1 (p = 0.03). .

This increase, calculated as the AIx, is a good expression of central aortic pressure. RESULTS: After accomplishing euthyroidism, the …
N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis.
Efrati S, Berman S, Siman-Tov Y, Lotan R, Averbukh Z, Weissgarten J, Golik A. Efrati S, et al. Among authors: golik a. Nephrol Dial Transplant. 2007 Jul;22(7):1873-81. doi: 10.1093/ndt/gfm113. Epub 2007 Mar 29. Nephrol Dial Transplant. 2007. PMID: 17400565
BACKGROUND: Renal failure is a threatening side-effect of NSAID administration, consequent to NSAID-mediated abrogation of prostaglandin synthesis and resultant renal ischaemia. ...We examined effects of NAC in a rat model of NSAID-induced renal failure. METHODS: Re …
BACKGROUND: Renal failure is a threatening side-effect of NSAID administration, consequent to NSAID-mediated abrogation of prostaglan …
The effect of losartan and losartan/hydrochlorothiazide fixed-combination on magnesium, zinc, and nitric oxide metabolism in hypertensive patients: a prospective open-label study.
Koren-Michowitz M, Dishy V, Zaidenstein R, Yona O, Berman S, Weissgarten J, Golik A. Koren-Michowitz M, et al. Among authors: golik a. Am J Hypertens. 2005 Mar;18(3):358-63. doi: 10.1016/j.amjhyper.2004.09.019. Am J Hypertens. 2005. PMID: 15797654 Clinical Trial.
Patients were treated with losartan 50 mg/day for 4 weeks followed by a fixed combination of 50 mg losartan and 12.5 mg hydrochlorothiazide for 4 weeks more. ...RESULTS: Treatment with losartan resulted in a significant increase in the urinary Zn/creatinine ratio (f …
Patients were treated with losartan 50 mg/day for 4 weeks followed by a fixed combination of 50 mg losartan and 12.5 mg hydrochloroth …
ACE inhibitors and survival of hemodialysis patients.
Efrati S, Zaidenstein R, Dishy V, Beberashvili I, Sharist M, Averbukh Z, Golik A, Weissgarten J. Efrati S, et al. Among authors: golik a. Am J Kidney Dis. 2002 Nov;40(5):1023-9. doi: 10.1053/ajkd.2002.36340. Am J Kidney Dis. 2002. PMID: 12407648
BACKGROUND: Cardiovascular disease is a leading cause of death in patients with end-stage renal disease (ESRD). Hypertension is a major risk factor for cardiovascular complications in these patients. ...Nevertheless, comparing the treated group with the untreated gr …
BACKGROUND: Cardiovascular disease is a leading cause of death in patients with end-stage renal disease (ESRD). Hypertension is a
The effect of N-acetylcysteine on renal function, nitric oxide, and oxidative stress after angiography.
Efrati S, Dishy V, Averbukh M, Blatt A, Krakover R, Weisgarten J, Morrow JD, Stein MC, Golik A. Efrati S, et al. Among authors: golik a. Kidney Int. 2003 Dec;64(6):2182-7. doi: 10.1046/j.1523-1755.2003.00322.x. Kidney Int. 2003. PMID: 14633141 Clinical Trial.
BACKGROUND: Renal failure induced by radiographic contrast agents is a known complication of coronary angiography, especially among patients with chronic renal failure. ...METHODS: Patients with a serum creatinine concentration above 10(6) micromol/L undergoing coro …
BACKGROUND: Renal failure induced by radiographic contrast agents is a known complication of coronary angiography, especially among p …
The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients.
Koren S, Shemesh-Bar L, Tirosh A, Peleg RK, Berman S, Hamad RA, Vinker S, Golik A, Efrati S. Koren S, et al. Among authors: golik a. Diabetes Technol Ther. 2012 Jul;14(7):561-7. doi: 10.1089/dia.2011.0296. Epub 2012 Apr 18. Diabetes Technol Ther. 2012. PMID: 22512265 Clinical Trial.
Following a 1-month washout period, a crossover switch from glibenclamide to sitagliptin and vice versa was performed for an additional 3 months. ...CONCLUSIONS: Sitagliptin, but not glibenclamide, demonstrated a significant beneficial effect on BMI and trigl …
Following a 1-month washout period, a crossover switch from glibenclamide to sitagliptin and vice versa was performed for an a …
Consumption of herbal remedies and dietary supplements amongst patients hospitalized in medical wards.
Goldstein LH, Elias M, Ron-Avraham G, Biniaurishvili BZ, Madjar M, Kamargash I, Braunstein R, Berkovitch M, Golik A. Goldstein LH, et al. Among authors: golik a. Br J Clin Pharmacol. 2007 Sep;64(3):373-80. doi: 10.1111/j.1365-2125.2007.02878.x. Epub 2007 Apr 10. Br J Clin Pharmacol. 2007. PMID: 17425631 Free PMC article.
The importance of the pharmacist in reporting adverse drug reactions in the emergency department.
Ratz Y, Shafir I, Berkovitch S, Sharristh M, Jacoby M, Kozer E, Golik A, Berkovitch M, Bar-Haim S. Ratz Y, et al. Among authors: golik a. J Clin Pharmacol. 2010 Oct;50(10):1217-21. doi: 10.1177/0091270010361258. Epub 2010 Apr 23. J Clin Pharmacol. 2010. PMID: 20418507 No abstract available.
Long QT and death in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease is not related to electrolyte disorders.
Zilberman-Itskovich S, Rahamim E, Tsiporin-Havatinsky F, Ziv-Baran T, Golik A, Zaidenstein R. Zilberman-Itskovich S, et al. Among authors: golik a. Int J Chron Obstruct Pulmon Dis. 2019 May 20;14:1053-1061. doi: 10.2147/COPD.S196428. eCollection 2019. Int J Chron Obstruct Pulmon Dis. 2019. PMID: 31190790 Free PMC article.
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