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1,956 results

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Page 1
Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trial.
Feagan BG, Sands BE, Sandborn WJ, Germinaro M, Vetter M, Shao J, Sheng S, Johanns J, Panés J; VEGA Study Group. Feagan BG, et al. Lancet Gastroenterol Hepatol. 2023 Apr;8(4):307-320. doi: 10.1016/S2468-1253(22)00427-7. Epub 2023 Feb 1. Lancet Gastroenterol Hepatol. 2023. PMID: 36738762 Clinical Trial.
Patients were randomly assigned (1:1:1) using a computer-generated randomisation schedule to combination therapy (subcutaneous golimumab 200 mg at week 0, subcutaneous golimumab 100 mg at weeks 2, 6, and 10, and intravenous guselkumab 200 mg at weeks 0, 4, and 8, fo …
Patients were randomly assigned (1:1:1) using a computer-generated randomisation schedule to combination therapy (subcutaneous golimumab …
Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis.
Sandborn WJ, Feagan BG, Marano C, Zhang H, Strauss R, Johanns J, Adedokun OJ, Guzzo C, Colombel JF, Reinisch W, Gibson PR, Collins J, Järnerot G, Hibi T, Rutgeerts P; PURSUIT-SC Study Group. Sandborn WJ, et al. Gastroenterology. 2014 Jan;146(1):85-95; quiz e14-5. doi: 10.1053/j.gastro.2013.05.048. Epub 2013 Jun 2. Gastroenterology. 2014. PMID: 23735746 Clinical Trial.
We evaluated subcutaneous golimumab induction therapy in TNF-alpha antagonist-naive patients with moderate-to-severe UC despite conventional treatment. ...Rates of clinical remission and mucosal healing and mean changes in IBDQ scores were significantly greater in both …
We evaluated subcutaneous golimumab induction therapy in TNF-alpha antagonist-naive patients with moderate-to-severe UC despite conve …
Golimumab.
Mazumdar S, Greenwald D. Mazumdar S, et al. MAbs. 2009 Sep-Oct;1(5):422-31. doi: 10.4161/mabs.1.5.9286. Epub 2009 Sep 15. MAbs. 2009. PMID: 20065639 Free PMC article. Review.
Golimumab, a human anti-TNFalpha IgG1kappa monoclonal antibody, was approved in the US and Canada in April 2009 as a treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis, and is undergoing regulatory review in the EU for these indications. The …
Golimumab, a human anti-TNFalpha IgG1kappa monoclonal antibody, was approved in the US and Canada in April 2009 as a treatment for rh …
Golimumab (anti-TNF monoclonal antibody): where we stand today.
Melo AT, Campanilho-Marques R, Fonseca JE. Melo AT, et al. Hum Vaccin Immunother. 2021 Jun 3;17(6):1586-1598. doi: 10.1080/21645515.2020.1836919. Epub 2020 Dec 28. Hum Vaccin Immunother. 2021. PMID: 33369527 Free PMC article. Review.
Biological therapies, like TNF inhibitors, have been revolutionizing the course of these disorders. Golimumab is a transgenic anti-TNF monoclonal antibody that acts primarily by targeting and neutralizing TNF, thus preventing inflammation. ...This review charts the clinica …
Biological therapies, like TNF inhibitors, have been revolutionizing the course of these disorders. Golimumab is a transgenic anti-TN …
Golimumab-Associated Glomerulonephritis.
Agrawal N, Roy N, Naramala S, Konala VM, Adapa S, Dhingra H, Aronow WS. Agrawal N, et al. Am J Ther. 2021 Jan-Feb 01;28(1):e145-e147. doi: 10.1097/MJT.0000000000000946. Am J Ther. 2021. PMID: 33369915 No abstract available.
Golimumab for the treatment of axial spondyloarthritis.
Palazzi C, D'angelo S, Gilio M, Leccese P, Padula A, Olivieri I. Palazzi C, et al. Expert Opin Biol Ther. 2017 Jan;17(1):129-133. doi: 10.1080/14712598.2017.1256387. Epub 2016 Nov 9. Expert Opin Biol Ther. 2017. PMID: 27817204 Review.
In the field of axial spondyloarthritis, golimumab, a fully human monoclonal anti-TNFalpha administered subcutaneously every 4 weeks, has shown significant efficacy and good safety in patients with ankylosing spondylitis. ...Preliminary data concerning an open-label extens …
In the field of axial spondyloarthritis, golimumab, a fully human monoclonal anti-TNFalpha administered subcutaneously every 4 weeks, …
Golimumab-induced posterior reversible encephalopathy syndrome (PRES): a case-based review.
Çimen Güneş E, Çolak S, Tekgöz E, Çınar M, Yılmaz S. Çimen Güneş E, et al. Clin Rheumatol. 2023 Dec;42(12):3407-3410. doi: 10.1007/s10067-023-06771-w. Epub 2023 Sep 16. Clin Rheumatol. 2023. PMID: 37715081 Review.
The patient had the diagnoses of AS for 12 years and hypertension for 3 years and receiving golimumab and carvedilol. The patient was diagnosed with PRES based on the current clinical and diffusion cranial magnetic resonance imaging (MRI) findings. On suspicion of being th …
The patient had the diagnoses of AS for 12 years and hypertension for 3 years and receiving golimumab and carvedilol. The patient was …
Golimumab in inflammatory bowel diseases: present and future scenarios.
Dragoni G, Le Grazie M, Orlandini B, Rogai F. Dragoni G, et al. Clin J Gastroenterol. 2019 Feb;12(1):1-9. doi: 10.1007/s12328-018-0906-9. Epub 2018 Sep 11. Clin J Gastroenterol. 2019. PMID: 30206776 Review.
Golimumab is the third anti-TNF agent approved for the treatment of ulcerative colitis. ...Preliminary data also report golimumab efficacy in Crohn's disease with higher doses than in ulcerative colitis with an acceptable safety profile. ...
Golimumab is the third anti-TNF agent approved for the treatment of ulcerative colitis. ...Preliminary data also report golimumab …
Golimumab: A Review in Inflammatory Arthritis.
Frampton JE. Frampton JE. BioDrugs. 2017 Jun;31(3):263-274. doi: 10.1007/s40259-017-0217-6. BioDrugs. 2017. PMID: 28530020 Review.
Golimumab (Simponi( )), a fully human monoclonal antibody against tumour necrosis factor-alpha (TNFalpha), is given once monthly by subcutaneous injection. ...Thus, golimumab is an effective, generally well tolerated and potentially convenient option for the treatme …
Golimumab (Simponi( )), a fully human monoclonal antibody against tumour necrosis factor-alpha (TNFalpha), is given once monthly by s …
Golimumab for the treatment of ulcerative colitis.
Flamant M, Paul S, Roblin X. Flamant M, et al. Expert Opin Biol Ther. 2017 Jul;17(7):879-886. doi: 10.1080/14712598.2017.1327576. Epub 2017 May 16. Expert Opin Biol Ther. 2017. PMID: 28472597 Free PMC article. Review.
More recently, a third tumor necrosis factor antagonist, golimumab, was approved, extending the therapeutic approach for moderate-to-severe ulcerative colitis. Areas covered: In this review, the authors review the literature on the efficacy and safety of golimumab i …
More recently, a third tumor necrosis factor antagonist, golimumab, was approved, extending the therapeutic approach for moderate-to- …
1,956 results