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The vitamin D-antimicrobial peptide pathway and its role in protection against infection.
Gombart AF. Gombart AF. Future Microbiol. 2009 Nov;4(9):1151-65. doi: 10.2217/fmb.09.87. Future Microbiol. 2009. PMID: 19895218 Free PMC article. Review.
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.
Gombart AF, Borregaard N, Koeffler HP. Gombart AF, et al. FASEB J. 2005 Jul;19(9):1067-77. doi: 10.1096/fj.04-3284com. FASEB J. 2005. PMID: 15985530
Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues.
Gombart AF, O'Kelly J, Saito T, Koeffler HP. Gombart AF, et al. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):552-7. doi: 10.1016/j.jsbmb.2006.12.095. Epub 2006 Dec 23. J Steroid Biochem Mol Biol. 2007. PMID: 17368184
Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis.
Gombart AF, Bhan I, Borregaard N, Tamez H, Camargo CA Jr, Koeffler HP, Thadhani R. Gombart AF, et al. Clin Infect Dis. 2009 Feb 15;48(4):418-24. doi: 10.1086/596314. Clin Infect Dis. 2009. PMID: 19133797 Free PMC article.
Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.
Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M. Adams JS, et al. Among authors: gombart af. J Immunol. 2009 Apr 1;182(7):4289-95. doi: 10.4049/jimmunol.0803736. J Immunol. 2009. PMID: 19299728 Free PMC article.
Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
Gombart AF, Saito T, Koeffler HP. Gombart AF, et al. BMC Genomics. 2009 Jul 16;10:321. doi: 10.1186/1471-2164-10-321. BMC Genomics. 2009. PMID: 19607716 Free PMC article.
Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism.
Campbell Y, Fantacone ML, Gombart AF. Campbell Y, et al. Among authors: gombart af. Eur J Nutr. 2012 Dec;51(8):899-907. doi: 10.1007/s00394-012-0415-4. Epub 2012 Jul 15. Eur J Nutr. 2012. PMID: 22797470 Free PMC article. Review.
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.
Guo C, Rosoha E, Lowry MB, Borregaard N, Gombart AF. Guo C, et al. Among authors: gombart af. J Nutr Biochem. 2013 May;24(5):754-9. doi: 10.1016/j.jnutbio.2012.04.002. Epub 2012 Jul 25. J Nutr Biochem. 2013. PMID: 22841393 Free PMC article.
Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults.
Dixon BM, Barker T, McKinnon T, Cuomo J, Frei B, Borregaard N, Gombart AF. Dixon BM, et al. Among authors: gombart af. BMC Res Notes. 2012 Oct 24;5:575. doi: 10.1186/1756-0500-5-575. BMC Res Notes. 2012. PMID: 23095332 Free PMC article.
Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids.
Guo C, Sinnott B, Niu B, Lowry MB, Fantacone ML, Gombart AF. Guo C, et al. Among authors: gombart af. Mol Nutr Food Res. 2014 Mar;58(3):528-536. doi: 10.1002/mnfr.201300266. Epub 2013 Sep 14. Mol Nutr Food Res. 2014. PMID: 24039193 Free PMC article.
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