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2011 1
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Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.
Bushell E, Gomes AR, Sanderson T, Anar B, Girling G, Herd C, Metcalf T, Modrzynska K, Schwach F, Martin RE, Mather MW, McFadden GI, Parts L, Rutledge GG, Vaidya AB, Wengelnik K, Rayner JC, Billker O. Bushell E, et al. Among authors: gomes ar. Cell. 2017 Jul 13;170(2):260-272.e8. doi: 10.1016/j.cell.2017.06.030. Cell. 2017. PMID: 28708996 Free PMC article.
To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei knockout mutants, representing >50% of the genome, and created a phenotype database. ...The leve …
To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of …
Dexamethasone increased the survival rate in Plasmodium berghei-infected mice.
Moreira DR, Uberti ACMG, Gomes ARQ, Ferreira MES, da Silva Barbosa A, Varela ELP, Dolabela MF, Percário S. Moreira DR, et al. Among authors: gomes arq. Sci Rep. 2021 Jan 29;11(1):2623. doi: 10.1038/s41598-021-82032-7. Sci Rep. 2021. PMID: 33514836 Free PMC article.
The present study aimed to evaluate the effects of dexamethasone on the redox status, parasitemia evolution, and survival rate of Plasmodium berghei-infected mice. Two-hundred and twenty-five mice were infected with Plasmodium berghei and subjected to stimulation or …
The present study aimed to evaluate the effects of dexamethasone on the redox status, parasitemia evolution, and survival rate of Plasmod …
PfGBP2 is a novel G-quadruplex binding protein in Plasmodium falciparum.
Gurung P, Gomes AR, Martins RM, Juranek SA, Alberti P, Mbang-Benet DE, Urbach S, Gazanion E, Guitard V, Paeschke K, Lopez-Rubio JJ. Gurung P, et al. Among authors: gomes ar. Cell Microbiol. 2021 Apr;23(4):e13303. doi: 10.1111/cmi.13303. Epub 2021 Jan 18. Cell Microbiol. 2021. PMID: 33340385
Recent reports have identified the presence of G4s within the AT-rich genome of Plasmodium falciparum, the protozoan parasite causing malaria. In Plasmodium, potential G4-forming sequences (G4FS) are enriched in the telomeric and sub-telomeric regions of the genome …
Recent reports have identified the presence of G4s within the AT-rich genome of Plasmodium falciparum, the protozoan parasite causing …
Commitment issues in Plasmodium.
Gomes AR, Talman AM. Gomes AR, et al. Nat Rev Microbiol. 2016 Jan;14(1):4. doi: 10.1038/nrmicro.2015.9. Epub 2015 Dec 7. Nat Rev Microbiol. 2016. PMID: 26639781 No abstract available.
Nutrient sensing modulates malaria parasite virulence.
Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM. Mancio-Silva L, et al. Among authors: gomes ar. Nature. 2017 Jul 13;547(7662):213-216. doi: 10.1038/nature23009. Epub 2017 Jul 5. Nature. 2017. PMID: 28678779 Free PMC article.
Canonical nutrient-sensing pathways are presumed to be absent from the causative agent of malaria, Plasmodium, thus raising the question of whether these parasites can sense and cope with fluctuations in host nutrient levels. Here we show that Plasmodium blood-stage …
Canonical nutrient-sensing pathways are presumed to be absent from the causative agent of malaria, Plasmodium, thus raising the quest …
Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites.
Reid AJ, Talman AM, Bennett HM, Gomes AR, Sanders MJ, Illingworth CJR, Billker O, Berriman M, Lawniczak MK. Reid AJ, et al. Among authors: gomes ar. Elife. 2018 Mar 27;7:e33105. doi: 10.7554/eLife.33105. Elife. 2018. PMID: 29580379 Free PMC article.
Transcriptional variation in unicellular malaria parasites from the Plasmodium genus is associated with critical phenotypes including red blood cell invasion and immune evasion, yet transcriptional variation at an individual parasite level has not been examined in depth. . …
Transcriptional variation in unicellular malaria parasites from the Plasmodium genus is associated with critical phenotypes including …
Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites.
Gazanion E, Lacroix L, Alberti P, Gurung P, Wein S, Cheng M, Mergny JL, Gomes AR, Lopez-Rubio JJ. Gazanion E, et al. Among authors: gomes ar. PLoS Genet. 2020 Jul 6;16(7):e1008917. doi: 10.1371/journal.pgen.1008917. eCollection 2020 Jul. PLoS Genet. 2020. PMID: 32628663 Free PMC article.
Here, we carried out the most comprehensive genome-wide survey, to date, of G4s in the Plasmodium falciparum genome using G4Hunter, which identifies G4 forming sequences (G4FS) considering their G-richness and G-skewness. ...Overall, our study highlights G4s as important D …
Here, we carried out the most comprehensive genome-wide survey, to date, of G4s in the Plasmodium falciparum genome using G4Hunter, w …
Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites.
Fang H, Gomes AR, Klages N, Pino P, Maco B, Walker EM, Zenonos ZA, Angrisano F, Baum J, Doerig C, Baker DA, Billker O, Brochet M. Fang H, et al. Among authors: gomes ar. Nat Commun. 2018 Oct 12;9(1):4248. doi: 10.1038/s41467-018-06733-w. Nat Commun. 2018. PMID: 30315162 Free PMC article.
To identify relationships between phospho-signalling pathways, we here screen 294 genetic interactions among protein kinases in Plasmodium berghei. This reveals a synthetic negative interaction between a hypomorphic allele of the protein kinase G (PKG) and CDPK4 to control …
To identify relationships between phospho-signalling pathways, we here screen 294 genetic interactions among protein kinases in Plasmodiu …
Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes.
Gomes AR, Ravenhall M, Benavente ED, Talman A, Sutherland C, Roper C, Clark TG, Campino S. Gomes AR, et al. Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):174-180. doi: 10.1016/j.ijpddr.2017.03.001. Epub 2017 Mar 9. Int J Parasitol Drugs Drug Resist. 2017. PMID: 28376349 Free PMC article.
New antimalarial compounds are currently at various stages of clinical trials and regulatory evaluation. Using 2000 Plasmodium falciparum genome sequences, we investigated the genetic diversity of eleven gene-targets of promising antimalarial compounds and assessed their p …
New antimalarial compounds are currently at various stages of clinical trials and regulatory evaluation. Using 2000 Plasmodium falcip …
G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon.
Dombrowski JG, Souza RM, Curry J, Hinton L, Silva NRM, Grignard L, Gonçalves LA, Gomes AR, Epiphanio S, Drakeley C, Huggett J, Clark TG, Campino S, Marinho CRF. Dombrowski JG, et al. Among authors: gomes ar. Malar J. 2017 Jun 15;16(1):253. doi: 10.1186/s12936-017-1889-6. Malar J. 2017. PMID: 28619120 Free PMC article.
BACKGROUND: Plasmodium vivax parasites are the predominant cause of malaria infections in the Brazilian Amazon. ...
BACKGROUND: Plasmodium vivax parasites are the predominant cause of malaria infections in the Brazilian Amazon. ...
18 results